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Immune Complex Diseases: Cellular Mediators and the Pathogenesis of Inflammatory Tissue Injury Produced by Immune Complexes

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Experimental Models of Chronic Inflammatory Diseases

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 6))

Abstract

The injurious properties of tissue-localized immune complexes (ICs) have long been recognized. A variety of forms of the injurious process have proved amenable to study in experimental animals and this has led to an informative view of the pathogenetic factors involved. More recent application of this information to human disease processes, thought or shown to involve ICs, has provided one of the best examples of the successful application of the principle of gaining understanding of human disease by study of animal models.

This is publication number 1176 from the Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California 92037. This work was supported by USPHS grants AI 07007 and GMS 19322.

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References

  1. Arend, W.P., Mannik, M.: Studies of antigen-antibody complexes. II. Quantification of tissue uptake of soluble complexes in normal and complement depleted rabbits. J. Immunol. 107, 63 (1971)

    PubMed  CAS  Google Scholar 

  2. Becker, E.L., Henson, P.M.: In vitro studies of immunologically induced secretion of mediators from cells and related phenomena. Advanc. Immunol. 17, 93 (1973)

    Article  CAS  Google Scholar 

  3. Benveniste, J.: Platelet activating factor. In: Mediators of the Immediate Type Inflammatory Reactions. Rother, K., deWeck, A. (eds.). Basel: Karger 1977, in press

    Google Scholar 

  4. Benveniste, J., Henson, P.M., Cochrane, C.G.: Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils and a platelet activating factor. J. exp. Med. 136, 1356 (1972)

    Article  PubMed  CAS  Google Scholar 

  5. Cochrane, C.G.: Studies on the localization of circulating antigen-antibody complexes and other macromolecules in vessels. I. Structural studies. J. exp. Med. 118, 489–502 (1963a)

    Article  PubMed  CAS  Google Scholar 

  6. Cochrane, C.G.: Studies on the localization of circulating antigen-antibody complexes and other macromolecules in vessels. II. Pathogenetic and pharmacodynamic studies. J. exp. Med. 118, 503–513 (1963b)

    Article  PubMed  CAS  Google Scholar 

  7. Cochrane, C.G., Hawkins, D.: Studies on circulating immune complexes. III. Factors governing the ability of circulating complexes to localize in blood vessels. J. exp. Med. 127, 137–154 (1968)

    Article  PubMed  CAS  Google Scholar 

  8. Cochrane, C.G., Koffler, D.: Immune complex disease in experimental animals and man. Advanc. Immunol. 16, 185 (1973)

    Article  CAS  Google Scholar 

  9. Cochrane, C.G., Janoff, A.: The Arthus reaction: a model of neutrophil and complement-mediated injury. In: The Inflammatory Process, Vol. III. Zweifach, Grant, McCluskey (eds.). New York: Academic Press 1974, p. 85–162

    Google Scholar 

  10. Cochrane, C.G., Unanue, E.R., Dixon, F.J.: A role of polymorphonuclear leukocytes and complement in nephrotoxic nephritis. J. exp. Med. 122, 99–116 (1965)

    Article  PubMed  CAS  Google Scholar 

  11. Conroy, M.C., Ozols, J., Lepow, I.H.: Structural features and biologic properties of fragments obtained by limited proteolysis of C3. J. Immunol. 116, 1682–1687 (1976)

    PubMed  CAS  Google Scholar 

  12. DeShazo, C.V., Henson, P.M., Cochrane, C.G.: Acute immunologic arthritis in rabbits. J. clin. Invest. 51, 50–57 (1972a)

    Article  PubMed  CAS  Google Scholar 

  13. DeShazo, C.V., McGrade, M.T., Henson, P.M., Cochrane, C.G.: The effect of complement depletion on neutrophil migration in acute immunologic arthritis. J. Immunol. 108, 1414–1419 (1972b)

    PubMed  CAS  Google Scholar 

  14. Dixon, F.J., Feldman, J.D., Vasquez, J.: Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. exp. Med. 113, 899 (1961)

    Article  PubMed  CAS  Google Scholar 

  15. Fernandez, H., Henson, P.M., Hugli, T.E.: A single scheme for C3a and C5a isolation and characterization of chemotactic behavior. J. Immunol. 116, 1732 (1976)

    Google Scholar 

  16. Friedman, M., Byers, S.O.: Endothelial permeability in atherosclerosis. Arch. Path. 76, 99 (1963)

    PubMed  CAS  Google Scholar 

  17. Germuth, F.G., Jr.: A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J. exp. Med. 97, 257–282 (1953)

    Article  PubMed  Google Scholar 

  18. Germuth, F.G., Jr., Rodriguez, E.: Immunopathology of the Renal Glomerulus: Immune Complex Deposit and Antibasement Membrane Disease. Boston: Little, Brown and Co. 1973

    Google Scholar 

  19. Germuth, F.G. Jr., Senterfit, L.B., Pollack, A.D.: Immune complex disease. I. Experimental acute and chronic glomerulonephritis. Johns Hopk. med. J. 120, 225 (1967)

    Google Scholar 

  20. Gower, R.G., Sams, W.M. Jr., Thorne, E.G., Clayman, H.N.: Immune complex deposition in leukocytoclastic vasculitis. Clin. Res. 24, 493A (1976)

    Google Scholar 

  21. Halonen, M., Pinckard, R.N.: Intravascular effects of IgE antibody upon basophils, neutrophils, platelets and blood coagulation in the rabbit. J. Immunol. 115, 519–524 (1975)

    PubMed  CAS  Google Scholar 

  22. Halonen, M., Pinckard, R.N., Meng, A.L.: Characterization of IgE-induced systemic anaphylaxis in the rabbit. Lack of correlation between the intravascular release of histamine and anaphylactic sensitivity. J. Immunol. 111, 331 (1973)

    PubMed  CAS  Google Scholar 

  23. Hawkins, D., Cochrane, C.G.: Glomerular basement membrane damage in immunological glomerulonephritis. Immunology 14, 665–681 (1968)

    PubMed  CAS  Google Scholar 

  24. Hawn, C.V.Z., Janeway, C.A.: Histological and serological sequences in experimental hypersensitivity. J. exp. Med. 85, 571 (1947)

    Article  PubMed  CAS  Google Scholar 

  25. Henson, P.M.: The adherence of leukocytes and platelets induced by fixed IgG antibody or complement. Immunology 16, 107–121 (1968)

    Google Scholar 

  26. Henson, P.M.: Mechanisms of release of constituents from rabbit platelets by antigen-antibody complexes and complement. I. Lytic and nonlytic reactions. J. Immunol. 105, 476–489 (1970a)

    PubMed  CAS  Google Scholar 

  27. Henson, P.M.: Release of vasoactive amines from rabbit platelets induced by sensitized mononuclear leukocytes and antigen. J. exp. Med. 131, 287–306 (1970b)

    Article  PubMed  CAS  Google Scholar 

  28. Henson, P.M.: Release of biologically active constituents from blood cells and its role in antibody-mediated tissue injury. In: Progress in Immunology. Amos, D.B. (ed.). New York: Academic Press 1971, p. 156–171

    Google Scholar 

  29. Henson, P.M.: Pathologic mechanisms in neutrophil-mediated injury. Amer. J. Path. 68, 593–606 (1972)

    PubMed  CAS  Google Scholar 

  30. Henson, P.M.: Mechanisms of mediator release from inflammatory cells. In: Mediators of Inflammation. Weissmann, G. (ed.). New York: Plenum Publishing 1975, p. 9–50

    Google Scholar 

  31. Henson, P.M.: Activation and desensitization of platelets by platelet activating factor (PAF) derived from IgE-sensitized basophils. I. Characteristics of the secretory response. J. exp. Med. 143, 937 (1976)

    Article  PubMed  CAS  Google Scholar 

  32. Henson, P.M., Benveniste, J.: Antibody-leukocyte-platelet interactions. In: Second International Symposium on the Biochemistry of the Acute Allergic Reaction. Austen, K.F., Becker, E.L. (eds.). Oxford: Blackwell Scientific Publishers 1971, p. 111–126

    Google Scholar 

  33. Henson, P.M., Cochrane, C.G.: Antigen-antibody complexes, platelets and increased vascular permeability. In: Cellular and Humoral Mechanisms in Anaphylaxis and Allergy. Movat, H.Z. (ed.). Basel: Karger 1969, p. 129–143

    Google Scholar 

  34. Henson, P.M., Cochrane, C.G.: Acute immune complex disease in rabbits. The role of complement and of a leukocyte-dependent release of vasoactive amines from platelets. J. exp. Med. 133, 554–571 (1971)

    Article  PubMed  CAS  Google Scholar 

  35. Henson, P.M., Oades, Z.: Stimulation of human neutrophils by soluble and insoluble immunoglobulin aggregates. Secretion of granule constituents and increased oxidation of glucose. J. clin. Invest. 56, 1053–1061 (1975)

    Article  PubMed  CAS  Google Scholar 

  36. Henson, P.M., Pinckard, R.N.: Platelet activating factor (PAF) as a mediator in IgE anaphylaxis. Fed. Proc. 35, 516 (1976)

    Google Scholar 

  37. Kniker, W.T., Cochrane, C.G.: Pathogenic factors in vascular lesions of experimental serum sickness. J. exp. Med. 122, 83–98 (1965)

    Article  PubMed  CAS  Google Scholar 

  38. Kniker, W.T., Cochrane, C.G.: The localization of circulating immune complexes in experimental serum sickness. J. exp. Med. 127, 119 (1968)

    Article  PubMed  CAS  Google Scholar 

  39. Kniker, W.T., Guerra, F.A., Richards, S.: Immune complex disease in experimental animals and man. Advanc. Immunol. 16, 185 (1971)

    Google Scholar 

  40. Kravis, T.C., Henson, P.M.: The participation of basophils, platelets and platelet activating factor (PAF) in acute experimental immune complex disease in rabbits. Manuscript in preparation.

    Google Scholar 

  41. Morrison, D.C, Henson, P.M.: Release of mediators from mast cells and basophils induced by different stimuli. In: Modern Concepts and Developments in Immediate Hypersensitivity. Bach, M.K. (ed.). New York: Academic Press 1976, in press

    Google Scholar 

  42. Morrison, D.C, Kline, L., Henson, P.M.: Properdin pathway dependence of endotoxin (LPS) initiated complement dependent rabbit lysis. Manuscript in preparation

    Google Scholar 

  43. Mustard, J.F., Murphy, E.A., Rowsell, H.C., Downie, H.G.: Factors influencing thrombus formation in vivo. Amer. J. Med. 33, 621–647 (1962)

    Article  PubMed  CAS  Google Scholar 

  44. Osler, A.G., Lichtenstein, L.M., Levy, D.A.: In vitro studies of human reaginic allergy. Advanc. Immunol. 8, 183 (1968)

    Article  CAS  Google Scholar 

  45. Osler, A.G., Siraganian, R.P.: Immunologic mechanisms of platelet damage. Progr. Allergy 16, 450–498 (1972)

    Article  CAS  Google Scholar 

  46. Pinckard, R.N., Halonen, M., Henson, P.M.: The role of platelets in IgE-mediated anaphylaxis in rabbits. Manuscript in preparation

    Google Scholar 

  47. Pinckard, R.N., Halonen, M., Meng, A.L.: Preferential expression of antibovine serum albumin IgE homocytotropic antibody synthesis and anaphylactic sensitivity in the neonatal rabbit. J. Allergy clin. Immunol. 49, 301–310 (1972)

    Article  CAS  Google Scholar 

  48. Pincus, T., Haberkern, R., Christian, C.L.: Experimental chronic glomerulitis. J. exp. Med. 127, 819–832 (1968)

    Article  PubMed  CAS  Google Scholar 

  49. Rhyne, M.B., Germuth, F.G.: The relationship between serum complement activity and the development of allergic lesions in rabbits. J. exp. Med. 114, 633 (1961)

    Article  PubMed  CAS  Google Scholar 

  50. Simpson, I.J., Amos, N., Evans, D.J., Thomson, N.M., Peters, D.K.: Guinea-pig nephrotoxic nephritis. I. The role of complement and polymorphonuclear leucocytes and the effect of antibody subclass and fragments in the heterologous phase. Clin. exp. Immunol. 19, 499–511 (1975)

    PubMed  CAS  Google Scholar 

  51. Siqueria, M., Nelson, R.A.: Platelet agglutination by immune complexes and its possible role in hypersensitivity. J. Immunol. 86, 516–525 (1961)

    Google Scholar 

  52. Siraganian, R.P., Osler, A.G.: Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Demonstration of a fluid phase intermediate. J. Immunol. 106, 1244–1251 (1971)

    PubMed  CAS  Google Scholar 

  53. Siraganian, R.P., Sandberg, A.L., Alexander, A., Osler, A.G.: Platelet injury due to activation of the alternate complement pathway. J. Immunol. 110, 490–497 (1973)

    PubMed  CAS  Google Scholar 

  54. Till, G.: Leukocyte chemotaxis and its regulation. In: Mediators of the Immediate Type Inflammatory Reactions. Rother, K., de Week, A., (eds.). Basel: Karger 1977, in press

    Google Scholar 

  55. Ward, P.A.: Leukotoxin and leukotactic disorders. A review. Amer. J. Path. 77, 520 (1974)

    PubMed  CAS  Google Scholar 

  56. Wilson, C.B., Dixon, F.J.: Renal response to immunological injury. In: The Kidney. Brenner, B.M., Rector, F.C., Jr. (eds.). Philadelphia: Saunders 1976, p. 838–960

    Google Scholar 

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Authors
  1. P. M. Henson
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Editors and Affiliations

  1. The Mathilda and Terence Kennedy Institute of Rheumatology, Bute Gardens, Hammersmith, London, W6 7DW, Great Britain

    Leonard Eleazar Glynn

  2. Bayer Pharma-Forschungszentrum, Institut für Immunologie und Onkologie, Aprather Weg, 5600, Wuppertal 1, Fed. Rep. of Germany

    Horst Dieter Schlumberger

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Henson, P.M. (1977). Immune Complex Diseases: Cellular Mediators and the Pathogenesis of Inflammatory Tissue Injury Produced by Immune Complexes. In: Glynn, L.E., Schlumberger, H.D. (eds) Experimental Models of Chronic Inflammatory Diseases. Bayer-Symposium, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66573-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-66573-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66575-2

  • Online ISBN: 978-3-642-66573-8

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