Experimental Models of Chronic Inflammatory Diseases

  • Leonard Eleazar Glynn
  • Horst Dieter Schlumberger
Conference proceedings

Part of the Bayer-Symposium book series (BAYER-SYMP, volume 6)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Welcome

    1. H. D. Schlumberger
      Pages 1-2
  3. Experimental Models of Rheumatoid Lesions

    1. Front Matter
      Pages 3-3
    2. D. C. Dumonde, Elizabeth H. Jones, R. H. Kelly, Carolyn M. Oates
      Pages 4-27
    3. A. J. S. Davies, V. J. Wallis, E. Leuchars, I. Gery, T. Palmer
      Pages 35-40
  4. Experimental Models of Systemic Lupus

    1. Front Matter
      Pages 51-51
    2. N. Talal, J. R. Roubinian, R. Papoian, R. J. Pillarisetty
      Pages 52-58
    3. Natalie M. Teich, R. A. Weiss
      Pages 59-70
    4. A. M. Denman, D. J. Appleford, R. C. Imrie, M. J. Kinsley, B. K. Pelton, T. Schnitzer
      Pages 77-92
  5. Recent Approaches to Experimental Immune Complex Disease and Allergic Vasculitis

About these proceedings

Introduction

With the introduction of antibiotics acute inflammatory disease has ceased to be the dominant problem in general medical practice and its place is now increasingly occupied by chronic inflamma­ tory disease of which the rheumatic diseases constitute the most important group. lwo aspects of these diseases need to be consid­ ered, their aetiology and their pathogenesis. In some respects the latter is more important since even when the aetiology is known, as for example the haemolytic streptococcus in rheumatic fever, the mechanism by which the infecting agent accomplishes the development of the lesions that characterise the disease are still largely unknown. Still more so is this the case in rheuma­ toid arthritis and other chronic inflammations where the aetio­ logical agents are unknown. In an attempt to clarify the pathogenic mechanisms involved, sev­ eral attempts have been made to induce comparable lesions in ex­ perimental animals, partly to test underlying hypotheses, and partly to provide test situations for the trial of new therapeu­ tic agents. In view of the deficiencies in the current drug treat­ ment of chronic inflammatory disease there are many who feel that this is largely due to the inadequacy of the models avail­ able for test purposes.

Keywords

Arthritis antibiotics diseases inflammation pathogenesis rheumatic diseases rheumatism

Editors and affiliations

  • Leonard Eleazar Glynn
    • 1
  • Horst Dieter Schlumberger
    • 2
  1. 1.The Mathilda and Terence Kennedy Institute of RheumatologyHammersmith, LondonGreat Britain
  2. 2.Bayer Pharma-ForschungszentrumInstitut für Immunologie und OnkologieWuppertal 1Fed. Rep. of Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-66573-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1977
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-66575-2
  • Online ISBN 978-3-642-66573-8
  • Series Print ISSN 0067-4672
  • About this book