Abstract
The phenomenon of the preautomatic interval after cessation of an artificially induced tachycardia has been known since the animal experiments of Gaskell in 1884 [8]. During the last 15 years numerous electrophysiologic experiments have contributed to our understanding of the transient suppression in sinus node automaticity induced by rapid atrial pacing [1, 11, 13]. The results suggest that the initially negative chronotropic effect on the normal sinus node is at least partly due to a release of acetylcholine by the electrostimulation but that in addition alterations of the extracellular potassium and sodium concentration as well as changes in membrane permeability may be involved.
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Delius, W., Wirtzfeld, A. (1976). The Significance of the Sinus Node Recovery Time in the Sick Sinus Syndrome. In: Lüderitz, B. (eds) Cardiac Pacing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66356-7_4
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DOI: https://doi.org/10.1007/978-3-642-66356-7_4
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