Abstract
Halothane has been used in neurosurgery as an inhalation anesthetic for more than 10 years. Its hypotensive effect, mainly in combination with tubocurarines or ganglion blocking drugs, has been amply documented. The tendency towards a hypotensive reaction was explained by direct myocardial depression rather than by peripheral vascular dilatation. Exact measurements proved that a concentration of 0.5% halothane in the inhaled air leads to an increase of 11% in cerebral blood flow (1,2). Simultaneous measurements of intracranial pressure show a small increase, which can be explained by an augmentation of the brain volume (3,4).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
MCDOWALL, D.G.: The effects of clinical concentrations of halothane on the blood flow and oxygen uptake of the cerebral cortex. Brit. J. Anaesth. 39, 186–196 (1967).
WOLLMAN, H., ALEXANDER, S.C., COHEN, P.J., CHASE, P.E., MELMAN, E., BEHAR, M.G.: Cerebral circulation of man during halothane anaesthesia. Anesthesiology 25, 180–184 (1964).
JENNETT, B., BAKER, J., FITCH, W., MCDOWALL, D.G.: Effect of anesthesia on intracranial pressure in patients with space-occupying lesions. Lancet i, 61–64 (1969).
FITCH, W., MCDOWALL, D.G.: Effect of halothane on intracranial pressure gradients in the presence of intracranial space-occupying lesions. Brit. J. Anaesth. 43, 904–911 (1971).
CUSHING, H.: The blood pressure reaction of acute cerebral compression, illustrated by cases of intracranial hemorrhages. Am. J. Med. Sci. 125, 1017–1044 (1903).
MATAKAS, F., LEIPERT, M., FRANKE, J.: Cerebral blood flow during increased subarachnoid pressure. Acta Neurochir, 25, 19–36 (1971).
LANGFITT, T.W.: Increased intracranial pressure. Neurol. Surg. 1, 443–495 (1973).
FUCHS, E., SCHNEIDER, H.: Terminal vascular lesions in the dying brain after recirculation. In press.
MCNEALY, D.E., PLUM, F.: Brain stem dysfunction with supra-tentorial mass lesions. Arch. Neurol. 7, 26–48 (1962).
GERSTENBRAND, F., LÜCKING, C.H.: Die akuten traumatischen Hirnstammschäden. Arch. Psychiat. Nervenkr. 213, 264–281 (1970).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Fuchs, E., Wüllenweber, R. (1975). Is There Any Indication for Halothane Anesthesia in Neurosurgical Procedures with Increased ICP Today?. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_72
Download citation
DOI: https://doi.org/10.1007/978-3-642-66086-3_72
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66088-7
Online ISBN: 978-3-642-66086-3
eBook Packages: Springer Book Archive