Abstract
Glycerol from endogenous and exogenous sources is mainly eliminated in the liver (1) by conversion to alfa-glycero-phosphate. The elimination rate of glycerol appears to be proportional to the plasma concentration under physiologic conditions (2) but at higher concentrations, obtained by administration of glycerol, the elimination will become saturated (3,4). LUNDSGAARD (5) has shown that the elimination of glycerol from periphal blood after oral ingestion was reduced when ethanol was given simultaneously. Preliminary studies by LUNDQUIST et al. (6) demonstrated that this was due to a reduced splanchnic uptake of glycerol. In the present work these observations have been extended in order to elucidate the mechanism of the inhibitory effect of ethanol on glycerol elimination in the liver.
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References
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Tygstrup, N., Winkler, K., Lundquist, F. (1971). Ethanol Metabolism in Man, Studied by Liver Vein Catheterization (Effect of Ethanol on Glycerol Metabolism). In: Martini, G.A., Bode, C. (eds) Metabolic Changes Induced by Alcohol. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65131-1_18
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DOI: https://doi.org/10.1007/978-3-642-65131-1_18
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