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Alcohol-Induced Liver Injury

  • Chapter
Drug-Induced Hepatotoxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 121))

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Abstract

The prevalence of cirrhosis in population correlates well with per capita consumption of ethanol, regardless of the type of beverage consumed (GRANT et al. 1988; PARRISH et al. 1991). Moreover, it has been shown that the risk of developing cirrhosis increases with the total amount of ethanol consumed over a lifetime (LELBACH 1974, 1975). An individual who consumes about 200g ethanol (about 200z of 86 proof whisky) a day for 20 years has a 50% chance of manifesting cirrhosis (LELBACH 1974, 1975).

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Authors
  1. Y. Israel
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  2. E. Rubin
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Editors and Affiliations

  1. Department of Pathology Division of Experimental Pathology, University of Toronto, Medical Sciences Building, 1 King’s College Circle, M5S 1A8, Toronto, Ontario, Canada

    Ross G. Cameron M.D., Ph.D.

  2. Department of Clinical Biochemistry Banting Institute, University of Toronto, Room 521, 100 College Street, M5G 1L5, Toronto, Ontario, Canada

    George Feuer Ph.D.

  3. Parke-Davis Pharmaceutical Research Division Department of Pathology and Experimental Toxicology, Warner Lambert Company, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Felix A. de la Iglesia M.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Israel, Y., Rubin, E. (1996). Alcohol-Induced Liver Injury. In: Cameron, R.G., Feuer, G., de la Iglesia, F.A. (eds) Drug-Induced Hepatotoxicity. Handbook of Experimental Pharmacology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61013-4_25

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  • DOI: https://doi.org/10.1007/978-3-642-61013-4_25

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