Abstract
A large majority of the papers to appear in scientific journals in recent years on the subject of contrast media have focused on agents for magnetic resonance imaging (MRI) and ultrasonography (US). Iodinated contrast media have received relatively little attention in spite of their widespread use, which far exceeds that of agents for US and MRI. Possibly, scientific arguments concerning iodinated contrast media came to an end because current agents are so good that it seems unlikely that anything more than modest incremental improvements are possible (DAWSON 1995). Available contrast agents are so efficacious and safe that it is becoming more and more difficult to identify significant differences among them. Possibly our methodological approach to clinical trials needs to change if such small differences are to be detected. Clinical studies could be better focused on populations that are more susceptible to contrast media toxicity, and other scientific branches, such as pharmacoepidemiology, could help us to improve the methodological approach to clinical trials (STACUL and SPINAZZI 1997).
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Stacul, F. (1999). Currently Available Iodinated Contrast Media. In: Thomsen, H.S., Muller, R.N., Mattrey, R.F. (eds) Trends in Contrast Media. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59814-2_6
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DOI: https://doi.org/10.1007/978-3-642-59814-2_6
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