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Zusammenfassung

Die klinische Hyperthermic mit einer kontrollierten Temperaturerhöhung (40-44°C) im Zielgebiet wird in interdisziplinären onkologischen Behandlungskonzepten kombiniert mit Strahlen- und/oder Chemotherapie eingesetzt (Issels u. Falk 2001). Neben der direkten zytotoxischen Wirkung der Hyperthermic (Temperaturbereich > 42,5°c) besteht zusätzlich ein strahlen- und chemosensibilisierender sowie indirekt ein immunmodulatorischer Effekt im Hyperthermicrten Gewebe (Temperaturbereich 40-44°C).

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Literatur

  • Amichetti M, Griaff C, Fellin G, Pani G, Bolner A, Maluta S, Valdagni R (1993) Cisplatin, hyperthermia, and radiation (trimodal therapy) in patients with locally advanced head and neck tumors: a phase 1-11 study. Int J Radiation Oncology Biol Phys 26:801–807

    Article  CAS  Google Scholar 

  • Armour EP, McEachern D, Wang Z, Corry PM, Martinez A (1993) Sensitivity of human cells to mild hyperthermia. Cancer Res 53:2740–2744

    PubMed  CAS  Google Scholar 

  • Bauer KD, Henle KJ (1979) Arrhenius analysis of heat survival curves form normal and thermotolerant CHO cells. Radiation Res 78:251–263

    Article  PubMed  CAS  Google Scholar 

  • Bornstein BA, Zouranjian PS, Hansen JL, Fraser SM, Gelwan LA, Teicher BA, Svensson GK (1992) Local hyperthermia, radiation therapy, and chemotherapy in patients with local-regional recurrence of breast carcinoma. Int J. Radiation Oncology Biol Phys 25:79–85

    Article  Google Scholar 

  • Burris HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD, Hoff DD von (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15:2403–2413

    PubMed  CAS  Google Scholar 

  • Carter DL, MacFail JR, Clegg ST, Wan X, Prescott DM, Charles HC, Samulski TV (1998) Magnetic resonance thermometry during hyperthermia for human highgrade sarcoma. Int J Radiation Oncology Biol Phys 40:815–822

    Article  CAS  Google Scholar 

  • Dahl O (1994) Mechanisms of thermal enhancement of chemotherapeutic cytotoxicity. In: Urano M, Douple E (eds). Hyperthermia and Oncology, vol IV. VSP, Utrecht, pp 9–28

    Google Scholar 

  • Datta NR, Bose AK, Kapoor HK, Gupta S (1990) Head and neck cancers: results of thermoradiotherapy versus radiotherapy. Int J Hyperthermia 6:479–486

    Article  PubMed  CAS  Google Scholar 

  • Dewey WC (1994) Arrhenius relationships from the molecule and cell to the clinic. Int J Hyperthermia 10:457–483

    Article  PubMed  CAS  Google Scholar 

  • Emami B, Perez C, Leybovich L, Straube W, Gerichten D von (1987) Interstitial thermoradiotherapy in the treatment of malignant tumors. Int J Radiation Oncology Biol Phys 3:107–118

    CAS  Google Scholar 

  • Emami B, Scott C, Perez CA et al. (1996) Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistent human tumors: a prospectively controlled randomized study by the radiation therapy oncology group. Int J Radiation Oncology Biol Phys 34:1097–1104

    Article  CAS  Google Scholar 

  • Feldmann HJ, Molls M, Krümpelmann S, Stuschke M, Sack H (1993) Deep regional hyperthermia: comparison between the annular phased array and the sigma-60 applicator in the same patients. Int J Radiation Oncology Biol Phys 26:111–116

    Article  CAS  Google Scholar 

  • Hahn GM, Ning SC, Elizaga M, Kapp DS, Anderson RL (1989) A comparison of thermal responses of human and rodent cells. Int J Radiation Biology 56:817–825

    Article  CAS  Google Scholar 

  • Hand JW, Hind AJ (1986) A review of microwave and RF applicators for localised hyperthermia. In: Hand JW, James JR (eds) Physical techniques in clinical hyperthermia. Research Studies Press, Letchworth Hertfordshire, pp 98–148

    Google Scholar 

  • Haveman J, Rietbroek RC, Gererdink A, Rijn J van, Bakker PJM (1995) Effect of hyperthermia on the cytotoxicity of 2’,2’-difluorodeoxycytidine (gemcitabine) in cultered SW1573 cells. Int J Cancer 62:627–630

    Article  PubMed  CAS  Google Scholar 

  • Hendrick JP, Hartl FU (1993) Molecular chaperone functions of heat-shock proteins. Annu Rev Biochem 62:349–384

    Article  PubMed  CAS  Google Scholar 

  • Hiraoka M, Jo S, Akuta K, Nishimura Y, Takahashi M, Abe M (1987) Radiofrequency capacitive hyperthermia for deep-seated tumors. Cancer 60:128–135

    Article  PubMed  CAS  Google Scholar 

  • Iliakis G, Seaner R, Okayasu R (1990) Effects of hyperthermia on the repair of radiation-induced DNA single-and double-strand breaks in DNA double-strand break repair-deficient-and repair-proficient cell lines. Int J Hyperthermia 6:813–833

    Article  PubMed  CAS  Google Scholar 

  • Issels, RD, Abdel-Rahman, S, Wendtner et al. (2001) Neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for locally advanced primary or recur-rent high-risk soft tissue sarcomas (HR-STS) of adults: Long-term results of a phase II study. Eur J Cancer 37:1599–1608

    Article  PubMed  CAS  Google Scholar 

  • Issels R, Falk M (2001) Hyperthermia in oncology. Int J Hyperthermia 17:1–18

    Article  PubMed  Google Scholar 

  • Issels RD, Prenninger SW, Nagele A et al. (1990) Ifosfamide plus etoposide combined with regional hyperthermia in patients with locally advanced sarcomas: a phase II study. J Clin Oncol 8:1818–1829

    PubMed  CAS  Google Scholar 

  • Issels RD, Mittermüller I, Gerl A et al. (1991) Improvement of local control by regional hyperthermia combined with systemic chemotherapy (ifosfamide plus etoposide) in advanced sarcomas: updated report on 65 patients. Cancer J Res Clin Oncol 117:141–147

    Article  Google Scholar 

  • Kakehi M, Ueda K, Mukojima T, Hiraoka M, Seto O, Akanuma A, Nakatsugawa S (1990) Multi-institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancer of deep-seated organs. Int J Hyperthermia 6:719–740

    Article  PubMed  CAS  Google Scholar 

  • Kampinga HH, Turkel-Uygur N, Roti JL, Konings AWT (1989) The relationship of increased nudear protein content induced by hyperthermia to killing of HeLa S3 cells. Radiat Res 117:511–522

    Article  PubMed  CAS  Google Scholar 

  • Morimoto RA, Sarge KD, Abravaya K (1992) Transcriptional regulation of heat shock genes. A paradigm for inducible genomie responses. J Biol Chem 267:21987–21990

    PubMed  CAS  Google Scholar 

  • Multhoff G, Botzler C, Wiesnet M, Müller E, Meier T, Wilmanns W, Issels RD (1995) A stress-inducible 72-kDa heat shock protein (HSP72) is expressed of the surface of human tumor cells, but not on normal cells. Int J Cancer 61:272–279

    Article  PubMed  CAS  Google Scholar 

  • Multhoff G, Botzier C, Jennen L, Schmidt J, Ellwart J, Issels R (1997) Heat shock protein 72 on tumor cells. A recognition structure for NK cells. J Immunol 158:4341–4350

    PubMed  CAS  Google Scholar 

  • Oleson JR, Samulski TV, Leopold KA, Scott TC, Dewhirst MW, Dodge RK, George SL (1993) Sensitivity of hyperthermia trialoutcomes to temperature and time: implications for thermal goals of treatment. Int J Radiation Oncology Biol Phys 25:289–297

    Article  CAS  Google Scholar 

  • Overgaard J (1989) The current and potential role ofhyperthermia in radiotherapy. Int J Radiation Oncology Biol Phys 16:535–549

    Article  CAS  Google Scholar 

  • Overgaard J, Gonzalez Gonzalez D, Hulshof MCCM, Arcangeli G, Dahl O, Mella O, Bentzen SM for European Society for Hyperthermic Oncology (1995) Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. The Lancet 345:540–543

    Article  CAS  Google Scholar 

  • Peller M, Löffler R, Baur A et al. (1999) MRT-gesteuerte regionale Tiefen Hyperthermic. Radiologe 39:756–763

    Article  PubMed  CAS  Google Scholar 

  • Perez CA, Gillespie B, Pajak T, Horback NB, Emami B, Rubin P (1989) Quality assurance problems in clinical hyperthermia and their impact on therapeutic outcome. a report by the Radiation Therapy Oncology Group. Int J Radiation Oncology Biol Phys 16:551–558

    Article  CAS  Google Scholar 

  • Perez CA, Pajak T, Emami B, Hornback NB., Tupchong L, Rubin P (1991) Randomized phase III study comparing irradiation and hyperthermia with irradiation alone in superficial measurable tumors. Am J Clin Oncol 14:133–141

    Article  PubMed  CAS  Google Scholar 

  • Petrovich Z, Langholz B, Gibbs FA et al. (1989) Regional hyperthermia for advanced tumors: a clinical study of 353 patients. Int J Radiation Oncology Biol Phys 16:601–607

    Article  CAS  Google Scholar 

  • Rau B, Wust P, Hohenberger P et al. (1998) Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer. A phase II clinical trial. Annal of Surgery 227:380–289

    Article  CAS  Google Scholar 

  • Rietbroek RC, Schilthuis MS, Bakker PJM et al. (1997) Phase II trial of weekly locoregional hyperthermia and cisplatin in patients with a previously irradiated recurrent carcinoma of the uterine cervix. Cancer 79:935–942

    Article  PubMed  CAS  Google Scholar 

  • Romanowski R, Schött C, Issels R et al. (1993) Regionale Hyperthermie mit systemischer Chemotherapie bei Kindern und Jugendlichen: Durchführbarkeit und klinische Verläufe bei 34 intensiv vorbehandelten Patienten mit prognostisch ungünstigen Tumorerkrankungen. Klin Pädiatr 205:249–256

    Article  PubMed  CAS  Google Scholar 

  • Sapareto SA, Dewy WC (1984) Thermal dose determination in cancer therapy. Int J Radiation Oncology Biol Phys 10:787–800

    Article  CAS  Google Scholar 

  • Shibamoto Y, Nishimura Y, Abe M (1996) Intraoperative radiotherapy and hyperthermia for unresectable pancreatic cancer. Hepato-Gastroenterology 46:326–332

    Google Scholar 

  • Sneed PK, Stauffer PR, McDermott MW et al. (1998) Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost ± hyperthermia for glioblastoma multiforme. Int J Radiation Oncology Biol Phys 40:287–295

    Article  CAS  Google Scholar 

  • Streffer C. (1995) Molecular and cellular mechanisms of hyperthermia. In. Seegenschmiedt MH, Fessenden P, Vernon CC (eds) Thermoradiotherapy and thermocheotherapy. Springer, Berlin Heidelberg New York Tokyo, S 47–74

    Chapter  Google Scholar 

  • Sugimachi K, Kitamura K, Baba K, Ikebe M, Morita M, Matsuda H, Kuwano H (1992) Hyperthermia combined with chemotherapy and irradiation for patients with carcinoma of the oesophagus-A prospective randomized trial. Int J Hyperthermia 8:289–295

    Article  PubMed  CAS  Google Scholar 

  • Sugimachi K, Kuwano H, Ide H, Toge T, Saku M, Oshiumi Y (1994) Chemotherapy combined with or without hyperthermia for patients with oesophageal carcinoma: a prospective randomized trial. Int J Hyperthermia 10:485–493

    Article  PubMed  CAS  Google Scholar 

  • Tamura Y, Peng P, Liu K, Daou M, Srivastava PK (1997) Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science 278:117–120

    Article  PubMed  CAS  Google Scholar 

  • Towle LR (1994). Hyperthermia and drug resistance. In. Urano M, Douple E (eds) Hyperthermia and oncology, vol IV, VSP, pp 91–

    Google Scholar 

  • Urano M, Kuroda M, Nishimura Y (1999) For the clinical application of thermochemotherapy given at mild temperatures. Int J Hyperthermia 15:79–107

    Article  PubMed  CAS  Google Scholar 

  • Valdagni R, Amichetti M, Pani G (1988) Radical radiation alone versus radical radiation plus microwave hyperthermia for N3 (TNM-UICC) neck nodes: A prospective randomized clinical trial. Int J Radiation Oncology Biol Phys 15:13–24

    Article  CAS  Google Scholar 

  • Valdagni R, Amichetti M (1993) Report of long-term followup in a randomized trial comparing radiation therapy and radiation therapy plus hyperthermia to metastatic lymphnodes in stage IV head and neck patients. Int J Radiation Oncology Biol Phys 28:163–169

    Article  Google Scholar 

  • Vaupel P (1990) Pathophysiological mechanisms of hyperthermia in cancer therapy. In. Gautherie M (ed) Biological basis of oncologic thermotherapy. Springer, Berlin Heidelberg New York Tokyo, pp 74–134

    Google Scholar 

  • Vaupel PW, KeHeher DK (1995) Metabolic status and reaction to heat of normal and tumor tissue. In: Seegenschmiedt MH, Fessenden P, Vernon CC (eds) Thermoradiotherapy and thermocheotherapy. Springer, Berlin Heidelberg new York Tokyo, pp 157–176

    Chapter  Google Scholar 

  • Vernon CC, van der Zee J, Liu FF (1996) Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. Int J Radiation Oncology Biol Phys 35:731–744

    Article  CAS  Google Scholar 

  • Wells AD, Malkovskky M (2000) Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view. Immunol Today 21:129–132

    Article  PubMed  CAS  Google Scholar 

  • Wendtner, CM, Abdel-Rahman, S, Baumert, J et al. (2001) Treatment of primary, recurrent or inadequately resected high-risk soft tissue sarcomas (HR-STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia. Eur. J. Cancer 37:1609–1616

    Article  PubMed  CAS  Google Scholar 

  • Wessalowski R, Kruck H, Pape H, Kahn T, Willers R, Göbel U (1998) Hyperthermia for the treatment of patients with malignant germ cell tumors. A phase IIII study in ten children and adolescents with recurrent or refractory tumors. Cancer 82:793–800

    Article  PubMed  CAS  Google Scholar 

  • Zee J van, Gonzalez Gonzalez D, Rhoon GC van, Dijk JD van, Putten WL van, Hart AA (2000) Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 355:119–125

    Article  Google Scholar 

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Schlemmer, M., Abdel-Rahman, S., Issels, R.D. (2003). Hyperthermie. In: Boese-Landgraf, J., Gallkowski, U., Layer, G., Schalhorn, A. (eds) Regionale Tumortherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55839-9_27

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  • DOI: https://doi.org/10.1007/978-3-642-55839-9_27

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