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Molecular and Cellular Mechanisms of Hyperthermia

  • Chapter
Thermoradiotherapy and Thermochemotherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The success of tumor therapy is determined by the efficiency with which the killing of tumor cells is achieved under conditions of no or only slight damage to the normal tissues. Cell killing in this sense means that the clonogenicity of stem cells is destroyed by agents such as ionizing radiation, cytotoxic chemicals, or heat. Hyperthermia, the heating of cells to 40°-45°C, can act as a cytotoxic agent by itself or as a sensitizing agent in combination with ionizing radiation or cytotoxic drugs (Streffer 1990). The characteristics and mechanisms of sensitization by heat will be described in other chapters in the volume; therefore the focus of this chapter will be on the action of heat alone. During prolonged heating for several hours at temperatures of about 42°C and below or after a short heat shock, cells can become more thermorésistant. These phenomena of thermotolerance will also be described in a later chapter.

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Authors and Affiliations

  1. Department of Medical Radiobiology, Universitätsklinikum Essen, D-45122, Essen, Germany

    C. Streffer PhD, MD, h.c., Professor

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  1. C. Streffer PhD, MD, h.c., Professor
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Editors and Affiliations

  1. Strahlentherapeutische Klinik, Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany

    M. Heinrich Seegenschmiedt

  2. Radiation Oncology Physics Division, Stanford University Medical Center, SUMC Room S-044, Stanford, CA, 94305, USA

    Peter Fessenden PhD (Professor Emeritus, Radiation Oncology) (Professor Emeritus, Radiation Oncology)

  3. Department of Clinical Oncology, Hammersmith Hospital, Ducane Road, London, W12 OHS, UK

    Clare C. Vernon MA, FRCR

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Streffer, C. (1995). Molecular and Cellular Mechanisms of Hyperthermia. In: Seegenschmiedt, M.H., Fessenden, P., Vernon, C.C. (eds) Thermoradiotherapy and Thermochemotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57858-8_2

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