Abstract
It has been known since the 1940’s that genetic background has an effect on the susceptibility of mice to lymphoma induced by chemical carcinogens (Law 1941 ; Morton 1941) . In most cases, however, the biochemical basis for this variation in susceptibility has yet to be elucidated. We describe here our work on a system in which T cell lymphoma is induced in mice by exposure to the coal tar-derived carcinogen 3-methylcholanthrene (MCA) . One gene controlling the likelihood of developing lymphoma after exposure to MCA has been identified, and it appears that the remaining differences in susceptibility which cannot be attributed to this known locus may themselves stem from the action of a second single gene. This fact makes more feasible the mapping and identification of the biochemical entity involved.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Ishizaka, S.T., Lilly, F. (1988). Genetic Control of Murine Susceptibility to 3-Methylcholanthrene-Induced T Cell Lymphoma. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_36
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DOI: https://doi.org/10.1007/978-3-642-50059-6_36
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