Genetics of Immunological Diseases

  • Beverly Mock
  • Michael Potter

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 137)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Localizing and Cloning Genes

    1. Front Matter
      Pages 1-1
    2. S. D. M. Brown, N. Brockdorff, J. S. Cavanna, E. M. C. Fisher, A. J. Greenfield, M. F. Lyon et al.
      Pages 3-12
    3. D. A. Stephenson, S. G. Grant, L. J. Mullins, A. E. Scolese, A. J. O’Reilly, V. M. Chapman
      Pages 18-24
    4. R. D. Blank, G. R. Campbell, M. Pollak, P. D’Eustachio
      Pages 25-32
    5. C. Szpirer, J. Szpirer, M. Q. Islam, G. Levan
      Pages 33-38
    6. J. H. Nadeau, A. H. Reiner
      Pages 39-40
    7. N. D. Hastie, D. J. Porteous, W. Bickmore, J. Maule, V. van Heyningen
      Pages 41-46
    8. L. Stubbs, A. Poustka, D. Rohme, L. B. Russell, H. Lehrach
      Pages 47-52
  3. Complex Loci Involved in the Regulation of Developmental and Immunological Processes

    1. Front Matter
      Pages 53-53
    2. The Mouse t Complex

    3. Mouse Homeo Box Genes

      1. M. Fibi, M. Kessel, P. Gruss
        Pages 82-86
      2. A. Graham, P. W. H. Holland, A. Lumsden, R. Krumlauf, B. L. M. Hogan
        Pages 87-93
    4. Immunoglobulin Superfamily Genes

      1. M. R. Lieber, J. E. Hesse, K. Mizuuchi, M. Gellert
        Pages 94-99
      2. C. L. Peterson, B. Tsao, E. Kakkis, K. L. Calame
        Pages 100-106

About these proceedings

Introduction

The development of innovative molecular techniques such as pulse-field gel electro­ phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva­ tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved in a variety of developmental, autoimmune, neoplastic and infectious disease processes. In the first of three sections, a series of papers outline the most currently used methods of mapping and isolating genes whose products are unknown. The papers, following, are devoted to specific gene systems whose dysregulation is likely to produce mutant or disease phenotypes.

Keywords

diseases genetics immune response infectious disease

Editors and affiliations

  • Beverly Mock
    • 1
  • Michael Potter
    • 1
  1. 1.Laboratory of Genetics, National Cancer InstituteNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-50059-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-50061-9
  • Online ISBN 978-3-642-50059-6
  • Series Print ISSN 0070-217X
  • About this book