Abstract
There are different ways of dealing with biological problems in order to find an appropriate biometrical analysis. These approaches correspond to different objectives:
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to increase efficiency variance reduction, power optimization, etc.
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to decrease bias adjusting for covariables, including systematic factors, etc.
We will focus on the second objective in this paper, as we want to emphasize the importance of a proper understanding of the biological problem examining reproductive toxicity. The first objective is very important for the development of theoretical statistics, but not always of practical relevance. The bias induced by incorrect understanding of the biological problem, however, can be much larger than any possible gain in efficiency.
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© 1991 Springer-Verlag Berlin Heidelberg
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Meister, R., Chahoud, I., Jürgens, M., Iversen, F., Bochert, G. (1991). Biometrical Analysis of Strain Differences and Litter Effects. In: Hothorn, L. (eds) Statistical Methods in Toxicology. Lecture Notes in Medical Informatics, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48736-1_11
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DOI: https://doi.org/10.1007/978-3-642-48736-1_11
Publisher Name: Springer, Berlin, Heidelberg
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