Statistical Methods in Toxicology

1. Front Matter

   Pages N2-IV

   PDF

2. Introduction

   1. Modern Statistical Methods in Toxicology — An overview

      • Ludwig Hothorn

      Pages 1-4

3. Biostatistical Analysis of mutagenicity assays

   1. Statistical Analysis of the Ames Assay

      • Martin Schumacher, Claudia Schmoor

      Pages 5-19

   2. Statistical Analysis of the Micronucleus Test with the Fisher-Pitman Permutation Test

      • I. Leimer, H. Peil, J. Ellenberger

      Pages 20-24

   3. A Statistical Analysis of HGPRT-Test Data by Means of Computer Simulations

      • Stefan Rettig, Jürgen Lehn, Herbert G. Miltenburger

      Pages 25-34

   4. Measuring Intra-Assay Agreement for the Ames Salmonella Assay

      • Walter W. Piegorsch, Errol Zeiger

      Pages 35-41

   5. Tabular Overview of Statistical Methods Proposed for the Analysis of Ames Salmonella Assay Data

      • Joachim Vollmar, Lutz Edler

      Pages 42-48

4. Biostatistical analysis of long-term carcinogenicity studies

   1. Analyses of Longterm Carcinogenicity Studies

      • Jörg Kaufmann

      Pages 49-64

   2. Mathematical models for the initiating and promotive action of carcinogens

      • Lars Ehrenberg, Gianpaolo Scalia-Tomba

      Pages 65-78

   3. Statistical Problems in Estimating a Threshold in a Dose-Response Model

      • Fredrik Granath

      Pages 79-85

5. Biostatistical analysis of embryo-toxicity studies

   1. Per-Litter Analyses for Studies of Developmental Toxicity

      • Walter W. Piegorsch, Joseph K. Haseman

      Pages 86-95

   2. Biometrical Analysis of Strain Differences and Litter Effects

      • Reinhard Meister, Ibrahim Chahoud, Maike Jürgens, Frank Iversen, Gerd Bochert

      Pages 96-103

   3. Statistical Evaluation of Offspring Parameters in Embryotoxicity Studies

      • G. Rosenkranz, R. Uhl

      Pages 104-110

6. General principles in biostatidtical analysis of toxicological Studies

   1. General Statistical Principles in Testing of Toxicological Studies

      • Ludwig Hothorn

      Pages 111-131

   2. Determination of Endpoints in Acute and Chronic Toxicity Tests by Using Generalized Linear Models

      • Armand Maul

      Pages 132-138

   3. The Need for Software Validation in Routine Toxicology

      • H. D. Unkelbach

      Pages 139-149

   4. An Application of Mixed Model Anova for the Assesment of Motor Activity in Rat Behavioural Toxicity Studies

      • P. Repeto

      Pages 150-156

7. Back Matter

   Pages 157-161

   PDF

This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.

• ANOVA
• Generalized linear model
• Statistik
• Toxikologie
• evaluation
• mutagen
• research
• statistics
• toxicity
• toxicology

• Institute of Epidemiology and Biometry, German Cancer Research Center Heidelberg, Heidelberg, Germany

  Ludwig Hothorn

Policies and ethics