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Anti-Ischemic Effect of 1-Hydroxy Derivatives of Nitroxyl Bioantioxidants

  • Chapter
Bioactive Spin Labels

Abstract

The realization of pharmacological effects of nitroxyl radicals, i.e., their antitumor, radiosensitizing, anti-aggregating, and possibly, neuropsychotropic activity, appears to be largely determined by the free radical nitroxyl moiety [1]. Nitroxyls are known to be effective traps for reactive radicals, especially, for the radicals which are formed during oxidation of the organic compounds [2, 3]. Similar to their precursors, sterically hindered nitrous heterocycles, they prove to be effective antioxidants [2].

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Abbreviations

L:

lipids of biomembrane

L.; LO.; LOO. :

lipid radicals

\( O_{2}^{\underline{.}} \) :

superoxide anion

CBA:

breaking of the LPO chain by ē-acceptor antioxidant

CBD:

breaking of the LPO chain by ē-donoe antioxidant

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Author information

Authors and Affiliations

  1. Institute for Biotechnology, Moscow, 117246, Russian Federation

    Pavel G. Komarov, Alexander A. Morgunov, Mariana V. Bilenko & Renat I. Zhdanov

Authors
  1. Pavel G. Komarov
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  2. Alexander A. Morgunov
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  3. Mariana V. Bilenko
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  4. Renat I. Zhdanov
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Editor information

Editors and Affiliations

  1. Gene Therapeutics Laboratory, Institute for Biotechnology, Nauchnyi Proezd., 8, 117 246, Moscow, Russia

    Renat I. Zhdanov

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© 1992 Springer-Verlag Berlin, Heidelberg

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Komarov, P.G., Morgunov, A.A., Bilenko, M.V., Zhdanov, R.I. (1992). Anti-Ischemic Effect of 1-Hydroxy Derivatives of Nitroxyl Bioantioxidants. In: Zhdanov, R.I. (eds) Bioactive Spin Labels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48724-8_20

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  • DOI: https://doi.org/10.1007/978-3-642-48724-8_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48726-2

  • Online ISBN: 978-3-642-48724-8

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