Skip to main content

Comorbidity of Anxiety Disorders and Substance Use

  • Chapter
  • First Online:
Co-occurring Addictive and Psychiatric Disorders

Abstract

Generalized anxiety disorder, panic disorder with and without agoraphobia, social phobia, and specific phobias are frequently associated with substance use disorders. Since anxiety symptoms may occur as a consequence of withdrawal from drugs such as alcohol, opioids, or benzodiazepines or as a result of intoxication, the differential diagnosis between substance-induced anxiety disorders and comorbid psychiatric disorders can be difficult. Epidemiologic studies indicate a two to threefold increased risk for alcohol use disorders in patients with anxiety disorders; specifically, the prevalence of alcohol dependence but not abuse is increased. The increased risk for substance use can be explained only in part by self-medication or tension reduction. The best option for the treatment of comorbid patients might be standard treatment for substance use plus cognitive–behavioral therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

CBT:

Cognitive–behavioral therapy

GAD:

Generalized anxiety disorder

OR:

Odds ratio

PD:

Panic disorder

PTSD:

Posttraumatic stress disorder

SAD:

Social anxiety disorder

References

  • Avants SK, Margolin A, Kosten TR, Rounsaville BJ, Schottenfeld RS (1998) When is less treatment better? The role of social anxiety in matching methadone patients to psychosocial treatments. J Consult Clin Psychol 66(6):924–931

    Article  CAS  PubMed  Google Scholar 

  • Baldwin DS et al (2014) Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol 28(5):403–439

    Article  PubMed  Google Scholar 

  • Ballie A, Sannibal C (2007) Anxiety and drug and alcohol problems. In: Baker A, Velleman R (eds) Clinical handbook of co-existing mental health and drug and alcohol problems. Routledge, London, pp 197–217

    Google Scholar 

  • Bandelow B, Zohar J, Hollander E, Kasper S, Moller HJ, Allgulander C, Vega J (2008) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders—first revision. World J Biol Psychiatry 9(4):248–312. doi:10.1080/15622970802465807

    Article  PubMed  Google Scholar 

  • Bishop S, Duncan J, Brett M, Lawrence AD (2004) Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli. Nat Neurosci 7(2):184–188. doi:10.1038/nn1173

    Article  CAS  PubMed  Google Scholar 

  • Boschloo L, Vogelzangs N, Smit JH, van den Brink W, Veltman DJ, Beekman AT, Penninx BW (2011) Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders: findings from the Netherlands Study of Depression and Anxiety (NESDA). J Affect Disord 131(1–3):233–242. doi:10.1016/j.jad.2010.12.014

    Article  PubMed  Google Scholar 

  • Boschloo L, Vogelzangs N, van den Brink W, Smit JH, Veltman DJ, Beekman AT, Penninx BW (2013) Depressive and anxiety disorders predicting first incidence of alcohol use disorders: results of the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 74(12):1233–1240. doi:10.4088/JCP.12m08159

    Article  PubMed  Google Scholar 

  • Brady KT, Sinha R (2005) Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress. Am J Psychiatry 162(8):1483–1493. doi:10.1176/appi.ajp.162.8.1483

    Article  PubMed  Google Scholar 

  • Enquist J, Ferwerda M, Madhavan A, Hok D, Whistler JL (2012) Chronic ethanol potentiates the effect of neuropeptides in the basolateral amygdala and shows increased anxiolytic and anti-depressive effects. Neuropsychopharmacology 37(11):2436–2445. doi:10.1038/npp.2012.102

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Falk DE, Yi HY, Hilton ME (2008) Age of onset and temporal sequencing of lifetime DSM-IV alcohol use disorders relative to comorbid mood and anxiety disorders. Drug Alcohol Depend 94(1–3):234–245. doi:10.1016/j.drugalcdep.2007.11.022

    Article  PubMed Central  PubMed  Google Scholar 

  • Farris SG, Epstein EE, McCrady BS, Hunter-Reel D (2012) Do co-morbid anxiety disorders predict drinking outcomes in women with alcohol use disorders? Alcohol Alcohol 47(2):143–148. doi:10.1093/alcalc/agr155

    Article  PubMed Central  PubMed  Google Scholar 

  • Flensborg-Madsen T, Becker U, Gronbaek M, Knop J, Sher L, Mortensen EL (2011) Alcohol consumption and later risk of hospitalization with psychiatric disorders: prospective cohort study. Psychiatry Res 187(1–2):214–219. doi:10.1016/j.psychres.2010.11.016

    Article  PubMed  Google Scholar 

  • George DT, Nutt DJ, Dwyer BA, Linnoila M (1990) Alcoholism and panic disorder: is the comorbidity more than coincidence? Acta Psychiatr Scand 81(2):97–107

    Article  CAS  PubMed  Google Scholar 

  • Goodwin RD, Stein DJ (2013) Anxiety disorders and drug dependence: evidence on sequence and specificity among adults. Psychiatry Clin Neurosci 67(3):167–173. doi:10.1111/pcn.12030

    Article  PubMed Central  PubMed  Google Scholar 

  • Grant BF, Goldstein RB, Chou SP, Huang B, Stinson FS, Dawson DA, Compton WM (2009) Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Mol Psychiatry 14(11):1051–1066. doi:10.1038/mp.2008.41

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Grant BF, Hasin DS, Stinson FS, Dawson DA, June Ruan W, Goldstein RB, Huang B (2005) Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychol Med 35(12):1747–1759. doi:10.1017/S0033291705006069

    Article  PubMed  Google Scholar 

  • Hintz T, Mann K (2005) Comorbidity in alcohol use disorders: focus on mood, anxiety and personality. In: Rössler W, Stohler R (eds) Dual diagnosis. The evolving conceptual framework. Karger, Basel, pp 65–91

    Chapter  Google Scholar 

  • Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62(6):617–627. doi:10.1001/archpsyc.62.6.617

    Article  PubMed Central  PubMed  Google Scholar 

  • Kessler RC, Crum RM, Warner LA, Nelson CB, Schulenberg J, Anthony JC (1997) Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Arch Gen Psychiatry 54(4):313–321

    Article  CAS  PubMed  Google Scholar 

  • Kushner MG, Mackenzie TB, Fiszdon J, Valentiner DP, Foa E, Anderson N, Wangensteen D (1996) The effects of alcohol consumption on laboratory-induced panic and state anxiety. Arch Gen Psychiatry 53(3):264–270

    Article  CAS  PubMed  Google Scholar 

  • Liang W, Chikritzhs T, Lenton S (2011) Affective disorders and anxiety disorders predict the risk of drug harmful use and dependence. Addiction 106(6):1126–1134. doi:10.1111/j.1360-0443.2011.03362.x

    Article  PubMed  Google Scholar 

  • Marmorstein NR, Iacono WG, Malone SM (2010) Longitudinal associations between depression and substance dependence from adolescence through early adulthood. [Research Support, N.I.H., Extramural]. Drug Alcohol Depend 107(2–3):154–160. doi:10.1016/j.drugalcdep.2009.10.002

    Article  PubMed Central  PubMed  Google Scholar 

  • Marquenie LA, Schade A, Van Balkom AJ, Koeter M, Frenken S, van den Brink W, van Dyck R (2006) Comorbid phobic disorders do not influence outcome of alcohol dependence treatment. Results of a naturalistic follow-up study. Alcohol Alcohol 41(2):168–173. doi:10.1093/alcalc/agh252

    Article  PubMed  Google Scholar 

  • Melchior M, Prokofyeva E, Younès N, Surkan PJ, Martins SS (2014) Treatment for illegal drug use disorders: the role of comorbid mood and anxiety disorders. BMC Psychiatry 14:89. doi:10.1186/1471-244X-14-89

    Article  PubMed Central  PubMed  Google Scholar 

  • Merikangas KR, Mehta RL, Molnar BE, Walters EE, Swendsen JD, Aguilar-Gaziola S, Kessler RC (1998) Comorbidity of substance use disorders with mood and anxiety disorders: results of the International Consortium in Psychiatric Epidemiology. Addict Behav 23(6):893–907

    Article  CAS  PubMed  Google Scholar 

  • Merikangas KR, Zhang H, Avenevoli S, Acharyya S, Neuenschwander M, Angst J (2003) Longitudinal trajectories of depression and anxiety in a prospective community study: the Zurich Cohort Study. Arch Gen Psychiatry 60(10):993–1000. doi:10.1001/archpsyc.60.9.993

    PubMed  Google Scholar 

  • Norton PJ, Price EC (2007) A meta-analytic review of adult cognitive-behavioral treatment outcome across the anxiety disorders. J Nerv Ment Dis 195(6):521–531

    Article  PubMed  Google Scholar 

  • Olatunji BO et al (2010) Efficacy of congnitive behavioural therapy for anxiety disorders: a review of meta-analytic findings. J Psychiatr 33:517–577

    Google Scholar 

  • Robinson J, Sareen J, Cox BJ, Bolton JM (2011) Role of self-medication in the development of comorbid anxiety and substance use disorders: a longitudinal investigation. [Research Support, Non-U.S. Gov’t]. Arch Gen Psychiatry 68(8):800–807. doi:10.1001/archgenpsychiatry.2011.75

    Article  PubMed  Google Scholar 

  • Schade A, Marquenie LA, van Balkom AJ, Koeter MW, de Beurs E, van den Brink W, van Dyck R (2005) The effectiveness of anxiety treatment on alcohol-dependent patients with a comorbid phobic disorder: a randomized controlled trial. Alcohol Clin Exp Res 29(5):794–800

    Article  PubMed  Google Scholar 

  • Schellekens AF, de Jong CA, Buitelaar JK, Verkes RJ (2014) Co-morbid anxiety disorders predict early relapse after inpatient alcohol treatment. Eur Psychiatry. doi:10.1016/j.eurpsy.2013.08.006

    PubMed  Google Scholar 

  • Schneier FR, Foosel TE, Hasin DS et al (2010) Social anxiety disorder and alcohol use disorder co-morbidity in the National Epidemiologic Survey on Alcohol and related Conditions. Psychol Med 40:977–988

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schuckit MA, Hesselbrock V (1994) Alcohol dependence and anxiety disorders: what is the relationship? Am J Psychiatry 151(12):1723–1734

    CAS  PubMed  Google Scholar 

  • Teesson M, Slade T, Mills K (2009) Comorbidity in Australia: findings of the 2007 National Survey of Mental Health and Wellbeing. [Research Support, Non-U.S. Gov’t]. Aust N Z J Psychiatry 43(7):606–614. doi:10.1080/00048670902970908

    Article  PubMed  Google Scholar 

  • WĂĽsthoff LE, Waal H, GrĂĄwe RW (2014) The effectiveness of integrated treatment in patients with substance use disorders co-occurring with anxiety and/or depression–a group randomized trial. BMC Psychiatry 14:67. doi:10.1186/1471-244X-14-67

    Article  PubMed Central  PubMed  Google Scholar 

  • Yang H, Devous MD, Briggs RW, Spence JS, Xiao H, Kreyling N, Adinoff B (2013) Altered neural processing of threat in alcohol-dependent men. Alcohol Clin Exp Res 37(12):2029–2038. doi:10.1111/acer.12187

    Article  PubMed  Google Scholar 

  • Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Liang T (2014) Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats. Alcohol Clin Exp Res 38(5):1275–1283. doi:10.1111/acer.12379

    Article  CAS  PubMed  Google Scholar 

  • Zimmermann P, Wittchen HU, Hofler M, Pfister H, Kessler RC, Lieb R (2003) Primary anxiety disorders and the development of subsequent alcohol use disorders: a 4-year community study of adolescents and young adults. Psychol Med 33(7):1211–1222

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael Soyka .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Soyka, M. (2015). Comorbidity of Anxiety Disorders and Substance Use. In: Dom, G., Moggi, F. (eds) Co-occurring Addictive and Psychiatric Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45375-5_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-45375-5_11

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45374-8

  • Online ISBN: 978-3-642-45375-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics