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Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer

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RNA and Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 158))

Abstract

During recent years, it has become clear that regulation of mRNA stability is an important event in the control of gene expression. The stability of a large class of mammalian mRNAs is regulated by AU-rich elements (AREs) located in the mRNA 3′ UTRs. mRNAs with AREs are inherently labile but as a response to different cellular cues they can become either stabilized, allowing expression of a given gene, or further destabilized to silence their expression. These tightly regulated mRNAs include many that encode growth factors, proto-oncogenes, cytokines, and cell cycle regulators. Failure to properly regulate their stability can therefore lead to uncontrolled expression of factors associated with cell proliferation and has been implicated in several human cancers. A number of transfactors that recognize AREs and regulate the translation and degradation of ARE-mRNAs have been identified. These transfactors are regulated by signal transduction pathways, which are often misregulated in cancers. This chapter focuses on the function of ARE-binding proteins with an emphasis on their regulation by signaling pathways and the implications for human cancer.

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  1. Department of Molecular Biology and Genetics, University of Aarhus, DK-8000, Aarhus C, Denmark

    Christian Kroun Damgaard

  2. Division of Biological Sciences, University of California, San Diego, CA, 92093, USA

    Jens Lykke-Andersen

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  1. Dept. of Neurology, Robert H. Lurie Cancer Center Center for Genetic Medicine, Chicago, Illinois, USA

    Jane Y. Wu

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Damgaard, C.K., Lykke-Andersen, J. (2013). Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer. In: Wu, J. (eds) RNA and Cancer. Cancer Treatment and Research, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31659-3_7

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