RNA and Cancer

  • Jane Y. Wu

Part of the Cancer Treatment and Research book series (CTAR, volume 158)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt
    Pages 1-24
  3. Marieta Gencheva, Lixin Yang, Gong-Biao Lin, Ren-Jang Lin
    Pages 25-40
  4. Lulzim Shkreta, Brendan Bell, Timothée Revil, Julian P. Venables, Panagiotis Prinos, Sherif Abou Elela et al.
    Pages 41-94
  5. Claudia Ghigna, Silvano Riva, Giuseppe Biamonti
    Pages 95-117
  6. Jianzhong Jeff Xi
    Pages 119-137
  7. John T. Norton, Sui Huang
    Pages 139-152
  8. Christian Kroun Damgaard, Jens Lykke-Andersen
    Pages 153-180
  9. Kong Ruirui, Payal Ray, Mengxue Yang, Pushuai Wen, Li Zhu, Jianghong Liu et al.
    Pages 181-212
  10. Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani, Ryszard Kole
    Pages 213-233
  11. Nancy L. Krett, Shuo Ma, Steven T. Rosen
    Pages 235-245

About this book

Introduction

In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life.

This book reviews recent progress in selected areas of RNA processing in which information of particular relevance to cancer development and therapy has been obtained. It opens by examining the coupling between transcription and splicing. Three subsequent chapters describe in detail cancer-associated aberrant RNAs, new methodology for their detection, and the functional impact on expression of important genes, including oncogenes and tumor suppressor genes. Further topics include the role of microRNAs in cancer and the possible involvement of the perinucleolar compartment. The implications for cancer of regulation of mRNA stability by cellular signaling are discussed, and the importance of splicing defects in the regulation of cell death genes is examined. The potential for the development of oligonucleotide therapeutics is then reviewed before the final chapter considers clinical perspectives on the study of RNA defects in cancer.

All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers, leading to improved cancer diagnosis and treatment.

Keywords

Alternative splicing Cell death Imaging Microarray Tumor

Editors and affiliations

  • Jane Y. Wu
    • 1
  1. 1.Dept. of NeurologyRobert H. Lurie Cancer Center Center for Genetic MedicineChicagoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-31659-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-31658-6
  • Online ISBN 978-3-642-31659-3
  • Series Print ISSN 0927-3042
  • About this book