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Regeneration and Healing

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Autologous Resurfacing and Fracture Dowelling

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Abstract

There are two models for studying degradation and lamination of hyaline articular cartilage: the Silberberg mouse (Silberberg et al. 1965a, b) and the ACL-cut model on animals (Draenert and Draenert 1981). The Silberberg mouse develops during the first year of severe varus osteoarthritis in the knee joint. The varus deformation is induced by hormones. The osteoarthritis reveals all signs of a progredient degradation of the joint with the development of osteophytes (Fig. 4.1) and destruction of the hyaline cartilage, which is abraded in layers (Figs. 4.2 and 4.3). Simultaneous with the destruction, reparation processes with newly produced ground substance and proliferating cells can be observed (Fig. 4.4).

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Authors and Affiliations

  1. Zentrum fÜr Orthopädische Wissenschaften, Gabriel-Max-Straße 3, 81545, MÜnchen, Germany

    Prof. Dr. Klaus Draenert & Dr. Yvette Draenert

  2. Klinik fÜr Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Kirrberger Str., 66421, Homburg, Germany

    Prof. Dr. Tim Pohlemann

  3. Klinikum Rosenheim Unfallchirurgie, Pettenkoferstraße 10, 83022, Rosenheim, Germany

    Prof. Dr. Gerd Regel

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  1. Prof. Dr. Klaus Draenert
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Draenert, K., Draenert, Y., Pohlemann, T., Regel, G. (2012). Regeneration and Healing. In: Autologous Resurfacing and Fracture Dowelling. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24911-2_4

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