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Regeneration and Healing

  • Klaus Draenert
  • Yvette Draenert
  • Tim Pohlemann
  • Gerd Regel
Chapter

Abstract

There are two models for studying degradation and lamination of hyaline articular cartilage: the Silberberg mouse (Silberberg et al. 1965a, b) and the ACL-cut model on animals (Draenert and Draenert 1981). The Silberberg mouse develops during the first year of severe varus osteoarthritis in the knee joint. The varus deformation is induced by hormones. The osteoarthritis reveals all signs of a progredient degradation of the joint with the development of osteophytes (Fig. 4.1) and destruction of the hyaline cartilage, which is abraded in layers (Figs. 4.2 and 4.3). Simultaneous with the destruction, reparation processes with newly produced ground substance and proliferating cells can be observed (Fig. 4.4).

Keywords

Hyaline Cartilage Osteochondritis Dissecans Metaphyseal Bone Contact Healing Osteochondral Fracture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Klaus Draenert
    • 1
  • Yvette Draenert
    • 1
  • Tim Pohlemann
    • 2
  • Gerd Regel
    • 3
  1. 1.Zentrum fÜr Orthopädische WissenschaftenMÜnchenGermany
  2. 2.Klinik fÜr Unfall-, Hand- und WiederherstellungschirurgieUniversitätsklinikum des SaarlandesHomburgGermany
  3. 3.Klinikum Rosenheim UnfallchirurgieRosenheimGermany

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