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Tracer Development for Magnetic Particle Imaging

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Magnetic Particle Imaging

Part of the book series: Springer Proceedings in Physics ((SPPHY,volume 140))

Abstract

Magnetic particle imaging (MPI) allows quantitative evaluation of the spatial distribution of superparamagnetic iron oxide (SPIO) nanoparticles in the body. With a spatial resolution similar to magnetic resonance imaging (MRI), but superior temporal resolution, MPI has potential for different diagnostic applications. In addition to technical requirements, preclinical and clinical applications of this novel imaging modality require SPIO tracers optimized for MPI. This article discusses the suitability of Resovist as an MPI tracer and challenges and future prospects of tracer development.

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References

  1. Gleich, B., Weizenecker, J.: Tomographic imaging using the nonlinear response of magnetic particles. Nature 435, 1214–1217 (2005)

    Article  Google Scholar 

  2. Goodwill, P.W., Tamrazian, A., Croft, L.R., Lu, C.D., Johnson, E.M., Pidaparthi, R., et al.: Ferrohydrodynamic relaxometry for magnetic particle imaging. Applied Physics Letters 98, 262502 (2011)

    Article  Google Scholar 

  3. Weizenecker, J., Gleich, B., Rahmer, J., Dahnke, H., Borgert, J.: Three-dimensional real-time in vivo magnetic particle imaging. Physics in Medicine and Biology 54, L1 (2009)

    Article  Google Scholar 

  4. Gleich, B.: WO2004/091398 A2 (December 28, 2004)

    Google Scholar 

  5. Reimer, P., Tombach, B., Daldrup, H., Hesse, T., Sander, G., Balzer, T., et al.: Neue MR-Kontrastmittel in der Leberdiagnostik Erste klinische Ergebnisse mit hepatobiliärem Eovist®(Gadolinium-EOB-DTPA) und RES-spezifischem Resovist®(SH U 555 A). Der Radiologe 36, 124–133 (1996)

    Article  Google Scholar 

  6. Lawaczeck, R., Bauer, H., Frenzel, T., Hasegawa, M., Ito, Y., Kito, K., et al.: Magnetic iron oxide particles coated with carboxydextran for parenteral administration and liver contrasting. Pre-clinical profile of SH U555A. Acta Radiol. 38, 584–597 (1997)

    Google Scholar 

  7. Eberbeck, D., Wiekhorst, F., Wagner, S., Trahms, L.: How the size distribution of magnetic nanoparticles determines their magnetic particle imaging performance. Applied Physics Letters 98, 182502–182502 (2011)

    Article  Google Scholar 

  8. Ferguson, R.M., Minard, K.R., Krishnan, K.M.: Optimization of nanoparticle core size for magnetic particle imaging. J. Magn. Magn. Mater. 321, 1548–1551 (2009)

    Article  Google Scholar 

  9. Hyeon, T., Lee, S.S., Park, J., Chung, Y., Na, H.B.: Synthesis of highly crystalline and monodisperse maghemite nanocrystallites without a size-selection process. J. Am. Chem. Soc. 123, 12798–12801 (2001)

    Article  Google Scholar 

  10. Qiu, P., Mao, C.: Viscosity gradient as a novel mechanism for the centrifugation-based separation of nanoparticles. Adv. Mater. 23, 4880–4885 (2011)

    Article  Google Scholar 

  11. Bai, L., Ma, X., Liu, J., Sun, X., Zhao, D., Evans, D.G.: Rapid separation and purification of nanoparticles in organic density gradients. J. Am. Chem. Soc. 132, 2333–2337 (2010)

    Article  Google Scholar 

  12. Novak, J.P., Nickerson, C., Franzen, S., Feldheim, D.L.: Purification of molecularly bridged metal nanoparticle arrays by centrifugation and size exclusion chromatography. Anal. Chem. 73, 5758–5761 (2001)

    Article  Google Scholar 

  13. Hanauer, M., Pierrat, S., Zins, I., Lotz, A., Sönnichsen, C.: Separation of nanoparticles by gel electrophoresis according to size and shape. Nano. Lett. 7, 2881–2885 (2007)

    Article  Google Scholar 

  14. Moore, L.R., Rodriguez, A.R., Williams, P.S., McCloskey, K., Bolwell, B.J., Nakamura, M., et al.: Progenitor cell isolation with a high-capacity quadrupole magnetic flow sorter. Journal of Magnetism and Magnetic Materials 225, 277–284 (2001)

    Article  Google Scholar 

  15. Larsen, B.A., Haag, M.A., Serkova, N.J., Shroyer, K.R., Stoldt, C.R.: Controlled aggregation of superparamagnetic iron oxide nanoparticles for the development of molecular magnetic resonance imaging probes. Nanotechnology 19, 265102 (2008)

    Article  Google Scholar 

  16. Moghimi, S.M., Hunter, A.C., Murray, J.C.: Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53, 283–318 (2001)

    Google Scholar 

  17. Raynal, I., Prigent, P., Peyramaure, S., Najid, A., Rebuzzi, C., Corot, C.: Macrophage endocytosis of superparamagnetic iron oxide nanoparticles: mechanisms and comparison of ferumoxides and ferumoxtran-10. Invest. Radiol. 39, 56–63 (2004)

    Article  Google Scholar 

  18. Perrault, S.D., Walkey, C., Jennings, T., Fischer, H.C., Chan, W.C.: Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett. 9, 1909–1915 (2009)

    Article  Google Scholar 

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Correspondence to Harald Kratz .

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Kratz, H., Eberbeck, D., Wagner, S., Schnorr, J., Taupitz, M. (2012). Tracer Development for Magnetic Particle Imaging. In: Buzug, T., Borgert, J. (eds) Magnetic Particle Imaging. Springer Proceedings in Physics, vol 140. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24133-8_20

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