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Akutes Nierenversagen und Nierenersatzverfahren

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Die Anästhesiologie

Zusammenfassung

Das akute Nierenversagen (»acute renal failure«) tritt gehäuft bei Intensivpatienten auf und wird durch eine verminderte Organdurchblutung und eine Vielzahl von Nephrotoxinen bedingt. Die Nierenfunktion hat einen hohen prädiktiven Wert für die Prognose des gesamten Krankheitsverlaufs. Gleichzeitig moduliert die Niere eine Vielzahl von Prozessabläufen im menschlichen Organismus und ist damit an der Pathophysiologie von Krankheitsabläufen beteiligt. Im Rahmen dieser Erkenntnisse wurde der Begriff des »acute renal failure« in der medizinischen Fachliteratur durch »acute kidney injury« (AKI) ersetzt. Der neue Begriff erlaubt die Beschreibung des schrittweisen Versagens der Niere, dessen Therapie neben der Behandlung der Grunderkrankung des Gesamtorganismus die apparative Nierenersatztherapie sowie supportive intensivmedizinische Maßnahmen umfasst.

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Literatur

  1. Anon, Deutsche Interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin (DIVI) (2007) Leitlinie (Nr. 040/004) Akutes Nierenversagen. www.awmf-online.de

  2. Bellomo R, Kellum JA, Ronco C (2004) Defining acute renal failure: Physiological principles. Intensive Care Med 30: 33–37

    Article  PubMed  Google Scholar 

  3. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: The second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit Care 8: R204–212

    Article  PubMed  Google Scholar 

  4. Bingold TM, Scheller B, Zwissler B, Wissing H (2007) Renal replacement therapy in the intensive care unit: current aspects. Anaesthesist 56: 1105–1114

    Article  PubMed  CAS  Google Scholar 

  5. Bock HA (1997) Pathogenesis of acute renal failure: New aspects. Nephron 76: 130–142

    Article  PubMed  CAS  Google Scholar 

  6. Brezis M, Rosen S (1995) Hypoxia of the renal medulla – its implicationsfor disease. New Engl J Med 332: 647–655

    Article  PubMed  CAS  Google Scholar 

  7. Briguori C, Airoldi F, D‘Andrea D et al. (2007) Renal insufficiency following contrast media administration trial (remedial): A randomized comparison of 3 preventive strategies. Circulation 115: 1211–1217

    PubMed  CAS  Google Scholar 

  8. Briguori C, Quintavalle C, De Micco F, Condorelli G (2011) Nephrotoxicity of contrast media and protective effects of acetylcysteine. Arch Toxicol 85: 165–173

    Article  PubMed  CAS  Google Scholar 

  9. Burchardi H (1998) History and development of continuous renal replacement techniques. Kidney Int 53 (Suppl 66): S120–S124

    Google Scholar 

  10. Dart AB, Mutter TC, Ruth CA, Taback SP (2010) Hydroxyethyl starch (hes) versus other fluid therapies: Effects on kidney function. Cochrane Database Syst Rev: CD007594

    Google Scholar 

  11. Dehne MG, Klein TF, Muhling J et al. (2001) Impairment of renal function after cardiopulmonary bypass is not influenced by dopexamine. Ren Fail 23: 217–230

    Article  PubMed  CAS  Google Scholar 

  12. De Mendonca A, Vincent JL, Suter PM et al. (2000) Acute renal failure in the ICU: Risk factors and outcome evaluated by the SOFA score. Intensive Care Med 26: 915–921

    Article  PubMed  Google Scholar 

  13. Druml W (1992) Metabolic alterations in acute renal failure. Contrib Nephrol 98: 59–66

    PubMed  CAS  Google Scholar 

  14. Du J, Zhang L, Yang Y et al. (2010) ATP depletion-induced actin rearrangement reduces cell adhesion via p38 mapk-hsp27 signaling in renal proximal tubule cells. Cell Physiol Biochem 25: 501–510

    Article  PubMed  CAS  Google Scholar 

  15. Evans RG, Gardiner BS, Smith DW, O‘Connor PM (2008) Intrarenal oxygenation: Unique challenges and the biophysical basis of homeostasis. Am J Physiol Renal Physiol 295: F1259–1270

    Article  PubMed  CAS  Google Scholar 

  16. Feng MG, Navar LG (2010) Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine a2b receptor activation. Am J Physiol Renal Physiol 299: F310–315

    Article  PubMed  CAS  Google Scholar 

  17. Geronemus R, Schneider N (1984) Continuous arteriovenous hemodialysis: a new modality for treatment of acute renal failure. SAIO Trans 30: 610

    CAS  Google Scholar 

  18. Haase M, Devarajan P, Haase-Fielitz A et al.(2011) The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury a multicenter pooled analysis of prospective studies. J Am Coll Cardiol 57: 1752–1761

    Article  PubMed  CAS  Google Scholar 

  19. Herget-Rosenthal S, Marggraf G, Husing J et al. (2004) Early detection of acute renal failure by serum cystatin C. Kidney Int 66: 1115–1122

    Article  PubMed  CAS  Google Scholar 

  20. Herrera GA (1994) Myoglobin and the kidney: An overview. Ultrastruct Pathol 18: 113–117

    Article  PubMed  CAS  Google Scholar 

  21. Heyman SN, Rosenberger C, Rosen S (2011) Acute kidney injury: Lessons from experimental models. Contrib Nephrol 169: 286–296

    Article  PubMed  Google Scholar 

  22. Ho E, Fard A, Maisel A (2010) Evolving use of biomarkers for kidney injury in acute care settings. Curr Opin Crit Care 16: 399–407

    Article  PubMed  Google Scholar 

  23. Karajala V, Mansour W, Kellum JA (2009) Diuretics in acute kidney injury. Minerva Anestesiol 75: 251–257

    PubMed  CAS  Google Scholar 

  24. Karvellas CJ, Farhat MR, Sajjad I et al. (2011) A comparison of early versus late initiation of renal replacement theapy in critical ill patients with acute kidney injury: a systematic review and meta-analysis. Crit Care 15: R72

    Article  Google Scholar 

  25. Kramer P, Wigger W, Rieger J, Matthaei D, Scheler F (1977) Arteriovenous hemofiltration: a new and simple method for treatment of overhydrated patients resistent to diuretics. Klin Wochenschr 55: 1121

    Article  PubMed  CAS  Google Scholar 

  26. Lauschke A, Teichgraber UK, Frei U, Eckardt KU (2006) Low-dose dopamine worsens renal perfusion in patients with acute renal failure. Kidney Int 69: 1669–1674

    Article  PubMed  CAS  Google Scholar 

  27. Lee YJ, Han HJ (2005) Effect of adenosine triphosphate in renal ischemic injury: Involvement of nf-kappa b. J Cell Physiol 204: 792–799

    Article  PubMed  CAS  Google Scholar 

  28. Lee YJ, Park SH, Jeung TO et al. (2005) Effect of adenosine triphosphate on phosphate uptake in renal proximal tubule cells: Involvement of PKC and p38MAPK. J Cell Physiol 205: 68–76

    Article  PubMed  CAS  Google Scholar 

  29. Levey AS, Bosch JP, Lewis JB et al. (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of diet in renal disease study group. Ann Intern Med 130: 461–470

    PubMed  CAS  Google Scholar 

  30. Lewis J, Salem MM, Chertow GM et al. (2000) Atrial natriuretic factor in oliguric acute renal failure. Anaritide acute renal failure study group. Am J Kidney Dis 36: 767–774

    Article  PubMed  CAS  Google Scholar 

  31. Liangos O, Perianayagam MC, Vaidya VS et al. (2007) Urinary n-acetylbeta-(d)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol 18: 904–912

    Article  PubMed  CAS  Google Scholar 

  32. Liangos O, Wald R, O‘Bell JW et al. (2006) Epidemiology and outcomes of acute renal failure in hospitalized patients: A national survey. Clin J Am Soc Nephrol 1: 43–51

    Article  PubMed  Google Scholar 

  33. Lisowska-Myjak B (2010) Serum and urinary biomarkers of acute kidney injury. Blood Purif 29: 357–365

    Article  PubMed  CAS  Google Scholar 

  34. Lonnemann G, Floege J, Kliem V, Brunkhorst R, Koch KM (2000) Extended daily veno-venous high-flux haemodialysis in patients with acute renal failure and multiple organ dysfunction syndrome using a single path batch dialysis system. Nephrol Dial Transplant 15: 1189–1193

    Article  PubMed  CAS  Google Scholar 

  35. Marenzi G, Assanelli E, Marana I et al. (2006) N-acetylcysteine and contrast-induced nephropathy in primary angioplasty. N Engl J Med 354: 2773–2782

    Article  PubMed  CAS  Google Scholar 

  36. Mehta RL, Kellum JA, Shah SV et al. (2007) Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: R31

    Article  Google Scholar 

  37. Miller TR, Anderson RJ, Linas SL et al. (1978) Urinary diagnostic indices in acute renal failure: A prospective study. Ann Intern Med 89: 47–50

    PubMed  CAS  Google Scholar 

  38. O‘Connor PM (2006) Renal oxygen delivery: Matching delivery to metabolic demand. Clin Exp Pharmacol Physiol 33: 961–967

    Article  PubMed  Google Scholar 

  39. Oppert M, Engel C, Brunkhorst FM et al. (2008) Acute renal failure in patients with severe sepsis and septic shock–a significant independent risk factor for mortality: Results from the german prevalence study. Nephrol Dial Transplant 23: 904–909

    Article  PubMed  Google Scholar 

  40. Ostermann M, Chang RW (2007) Acute kidney injury in the intensive care unit according to RIFLE. Crit Care Med 35: 1837–1843

    Article  PubMed  Google Scholar 

  41. Parikh CR, Abraham E, Ancukiewicz M, Edelstein CL (2005) Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol 16: 3046–3052

    Article  PubMed  CAS  Google Scholar 

  42. Patel NN, Rogers CA, Angelini GD, Murphy GJ (2011) Pharmacological therapies for the prevention of acute kidney injury following cardiac surgery: A systematic review. Heart Fail Rev (epub ahead of print)

    Google Scholar 

  43. Payen D, Mateo J, Cavaillon JM et al. for the Hemofiltration and Sepsis Group of the College National de Reanimation et de Médecine d‘Urgence des Hopitaux extra-Universitaires (2009) Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit Care Med 37: 803–810

    Article  PubMed  Google Scholar 

  44. Prakash J, Murthy AS, Vohra R, Rajak M, Mathur SK (2006) Acute renal failure in the intensive care unit. J Assoc Physicians India 54: 784–788

    PubMed  CAS  Google Scholar 

  45. Prowle JR, Echeverri JE, Ligabo EV, Ronco C, Bellomo R (2010) Fluid balance and acute kidney injury. Nat Rev Nephrol 6: 107–115

    Article  PubMed  Google Scholar 

  46. Ponikvar R (2003) Blood purification in the intensive care unit. Nephrol Dial Transplant 18 Suppl. 5: v63–v67

    Article  PubMed  Google Scholar 

  47. Rabindranath K, Adams J, Macleod AM, Muirhead N (2007) Intermittent versus continuous renal replacement therapy for acute renal failure in adults. Cochrane Database Syst Rev 3: CD003773

    PubMed  Google Scholar 

  48. Ratanarat R, Brendolan A, Ricci Z et al. (2006) Pulse high volume filtration in critical ill patients: a new approach for patients with septic shock. Semin Dial 19: 69–74

    Article  PubMed  Google Scholar 

  49. RENAL Replacement Therapy Study Investigators (2009) Intensity of continuous renal replacement therapy in critically ill patients. New Engl J Med 361: 1627–1638

    Article  Google Scholar 

  50. Ronco C, Bellomo R, Homel P et al. (2000) Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356: 26–30

    Article  PubMed  CAS  Google Scholar 

  51. Ronco C, Bragantini L, Brendolan A (1985) Arteriovenous hemodiafiltration (AVHDF) combined with continuous arteriovenous hemofiltration (CAVH). Trans Am Soc Artif Intern Organs 31: 349–353

    PubMed  CAS  Google Scholar 

  52. Rosen S, Heyman SN (2001) Difficulties in understanding human »Acute tubular necrosis: Limited data and flawed animal models. Kidney Int 60: 1220–1224

    Article  PubMed  CAS  Google Scholar 

  53. Saenz-Morales D, Escribese MM, Stamatakis K et al. (2006) Requirements for proximal tubule epithelial cell detachment in response to ischemia: Role of oxidative stress. Exp Cell Res 312: 3711–3727

    Article  PubMed  CAS  Google Scholar 

  54. Scheel PJ, Liu M, Rabb H (2008) Uremic lung: New insights into a forgotten condition. Kidney Int 74: 849–851

    Article  PubMed  Google Scholar 

  55. Schrier RW, Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351: 159–169

    Article  PubMed  CAS  Google Scholar 

  56. Trivedi H, Daram S, Szabo A, Bartorelli AL, Marenzi G (2009) High-dose n-acetylcysteine for the prevention of contrast-induced nephropathy. Am J Med 122: 874.e9–15

    Article  PubMed  Google Scholar 

  57. Tumlin JA, Finkel KW, Murray PT et al. (2005) Fenoldopam mesylate in early acute tubular necrosis: A randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis 46: 26–34

    Article  PubMed  CAS  Google Scholar 

  58. Uchino S, Kellum JA, Bellomo R et al. (2005) Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 294: 813–818

    Article  PubMed  CAS  Google Scholar 

  59. Venkataraman R (2008) Can we prevent acute kidney injury? Crit Care Med 36: S166–S171

    Article  PubMed  Google Scholar 

  60. Wing AJ, Broyer M, Brunner FP (1983) Combined report on regular dialysis and transplantation in Europe XII, 1982. Proc Eur Dial Transplant Assoc 20: 64–78

    Google Scholar 

  61. Zacharias M, Gilmore I, Herbison G, Sivalingam P, Walker R (2005) Interventions for protecting renal function in the perioperative period. Cochrane Database Syst Rev 3: CD003590

    PubMed  Google Scholar 

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Kaufmann, I., Haller, M., Schelling, G. (2012). Akutes Nierenversagen und Nierenersatzverfahren. In: Rossaint, R., Werner, C., Zwißler, B. (eds) Die Anästhesiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21125-6_84

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  • DOI: https://doi.org/10.1007/978-3-642-21125-6_84

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-21124-9

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