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Functional Neuroimaging in Sleep Disorders

  • Chapter
Nuclear Medicine in Psychiatry

Abstract

While the utilization of nuclear medicine methods for the assessment of sleep disorders is still in its infancy, early studies suggest that this is a promising area for future development. The assessment of brain function during sleep introduces a time-of-day variable into a neuroimaging study. Extensive preclinical knowledge of the neural mechanisms of sleep regulation helps to inform models of brain function that may be altered by sleep and by sleep disorders. Early studies show reliable increases in function in limbic and anterior paralimbic cortex in REM sleep and decreases in function in higher order cortical regions in known thalamocortical networks during NREM sleep. While most of the early work in this area has been devoted to the study of normal sleep mechanisms, a collection of studies in diverse sleep disorders such as sleep deprivation, depression, insomnia, dyssomnias, narcolepsy and sleep apnoea suggest that nuclear medicine has great potential in clarifying the pathophysiology of sleep disorders and potentially in guiding treatment strategies.

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Authors and Affiliations

  1. Sleep Neuroimaging Research Program, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O’Hara Street, Pittsburgh, PA, 15213, USA

    Eric A. Nofzinger

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  1. Eric A. Nofzinger
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Editors and Affiliations

  1. Division of Nuclear Medicine, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Andreas Otte  & Rudi A. Dierckx  & 

  2. University Department of Psychiatry, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Kurt Audenaert  & Kees van Heeringen  & 

  3. Department of Medical Imaging Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium

    Kathelijne Peremans

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Nofzinger, E.A. (2004). Functional Neuroimaging in Sleep Disorders. In: Otte, A., Audenaert, K., Peremans, K., van Heeringen, K., Dierckx, R.A. (eds) Nuclear Medicine in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18773-5_26

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  • DOI: https://doi.org/10.1007/978-3-642-18773-5_26

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