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β-CIT SPECT demonstrates reduced availability of serotonin transporters in patients with Fatal Familial Insomnia

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Summary.

Fatal familial insomnia (FFI) is a rare hereditary human prion disease with unique clinical features including progressive sleep impairment and autonomic dysfunction. The serotonergic system is considered to be involved in the regulation of the sleep-wake cycle. In this study we demonstrate a reduced availability of serotonin transporters of 57% and 73% respectively in a thalamus-hypothalamus region of two FFI patients examined with β-CIT SPECT as compared to age-expected control values.

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Authors and Affiliations

  1. Institute of Neurology, and, , , , , , AT

    S. Klöppel & G. G. Kovács

  2. Department of Neurology, University of Vienna, Austria, , , , , , AT

    W. Pirker, T. Brücke & G. Almer

Authors
  1. S. Klöppel
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  2. W. Pirker
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  3. T. Brücke
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  4. G. G. Kovács
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  5. G. Almer
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Received September 20, 2001; accepted February 22, 2002

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Klöppel, S., Pirker, W., Brücke, T. et al. β-CIT SPECT demonstrates reduced availability of serotonin transporters in patients with Fatal Familial Insomnia. J Neural Transm 109, 1105–1110 (2002). https://doi.org/10.1007/s007020200093

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  • DOI: https://doi.org/10.1007/s007020200093

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