Zusammenfassung
Lymphome des Magens sind definiert als Lymphome, die vom Magen oder direkt benachbarten regionären Lymphknoten ausgehen. Lymphome werden als primäre Magenlymphome bezeichnet, wenn die Haupttumormasse im Magen lokalisiert ist (Isaacson et al. 2001). Die Mehrzahl der Magenlymphome sind hochmaligne B-Zell-Lymphome, von denen wiederum ein Großteil durch Progression von niedrigmalignen Lymphomen des mukosaassoziierten lymphatischen Systems (MALT) entsteht. Die niedrigmalignen Lymphome sind meistens B-Zell-Lymphome vom MALT-Typ. Weitere Lymphomentitäten sind Mantelzell-, Burkitt-und T-Zell-Lymphome.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Andersson J, Sjogren H, Sjogren H et al. (2002) The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors. Am J Pathol 160:15–22
Berman J, O’Leary TJ (2001) Gastrointestinal stromal tumor workshop. Hum Pathol 32:578–582
Chott A (2003) Pathology of intestinal lymphomas. Pathologe24:15–27
Dagher R, Cohen M, Williams Get al. (2002) Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin Cancer Res 8:3034–3038
Dallenbach FE, Coupland SE, Stein H (2000) Marginal zone lymphomas:extranodal MALT type, nodal and splenic. Pathologe 21:162–177
Du MQ, Isaacson PG (2002) Gastric MALT lymphoma: from aetiology to treatment. Lancet Oncol 3:97–104
Hirota S, Osozaki K, Moriyama Y et al. (1998) Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science (Wash DC) 279:577–580
Hussel T, Isaacson PG, Crabtree JE, Spencer J (1993) The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 342:571–574
Isaacson PG, Müller-Hermelink H, Piris MA et al. (2001) Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) WHO classification of tumours: Pathology and genetics tumours of haematopoietic and lymphoid tissues. WHO, Genf, pp 157–160
Joensuu H, Roberts PJ, Sarlomo-Rikala M et al. (2001) Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 344:1052–1056
Liu H, Ruskone-Fourmestraux A, Lavergne-Slove A et al. (2000) Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet 357:39–40
Liu H, Ye H, Ruskone-Forumestraux A et al. (2002) T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to Helicobacter pylori eradication. Gastroenterology 122:1286–1294
Miettinen M, Blay LY, Sobin LH (2001) Mesenchymal tumors of the stomach. In: Hamilton SR, Aaltonrn LA (eds) WHO classification of tumours: Tumours of the digestive system. WHO, Genf, pp 62–65
Miettinen M, Majidi M, Lasota J (2002) Pathology and diagnostic criteria of gastrointestinal stroma tumors (GISTs): a review. Eur J Cancer 38 Suppl 5:39–51
van Oosterom AT, Judson I, Verweij J et al. (2001) Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours:a phase I study. Lancet 358:1421–1423
Watanabe M, Moriyama Y (2002) Primary gastric T-cell lymphoma without human T-lymphotropic virus type 1: report of a case. Surg Today 32: 525–30
Wotherspoon AC, Dogan A, Du MQ (2002) Mucosa-associated lymphoid tissue lymphoma. Curr Opin Hematol 9:50–5
Wotherspoon AC, Doglioni C, Diss TC et al. (1993) Regression of primary lowgrade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 342:575–577
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Tannapfel, A. (2004). Pathologische Morphologie der Magenlymphome und der gastrointestinalen Stromatumoren. In: Management des Magen- und Ösophaguskarzinoms. Onkologie aktuell. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18700-1_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-18700-1_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62254-0
Online ISBN: 978-3-642-18700-1
eBook Packages: Springer Book Archive