Abstract
Like many of its modern neighboring Arab countries, Jordan was part of the Ottoman Empire until the end of World War I. Under the mandate of the British government in 1923, Jordan became a political entity known as “Transjordan.” However, Jordan gained its independence and was declared a Kingdom in 1946. In 1948, Jordan witnessed a mass migration of at least 700,000 Palestinians as a result of the creation of the state of Israel. The union of Transjordan and the West Bank (of Palestine) in 1950 produced the current name of the Hashemite Kingdom of Jordan. As a result of the 1967 war, the West Bank fell under Israel’s occupation and another wave of Palestinian refugees moved to Jordan adding to its population. Geographically, Jordan is almost entirely landlocked, with the port of Aqaba in the far south being its only outlet to the red sea. Palestine and Israel separate Jordan from the Mediterranean sea, Saudi Arabia lies to the south and east, Iraq to the northeast, and Syria to the north (Fig. 11.1). Three climate zones characterize Jordan, running from the west to the east of the country. These zones include the Jordan Valley which is largely below sea level and considered semitropical; the highlands east of the Jordan Valley which can be considered to have a Mediterranean climate; and the low-lying desert to the east of the highlands. Jordan is about the size of the state of Indiana, USA. Over 80% of Jordan’s land is characterized by semi-desert conditions with some scattered wetlands including the Azraq Basin. Administratively, Jordan is divided into 12 governorates, which are grouped into three regions – the North region (Irbid, Jarash, Ajloun, and Mafraq), the Central region (Amman, Zarqa, Balqa, and Madaba), and the South region (Karak, Tafielah, Ma’an, and Aqaba) (Fig. 11.1). The major cities are Amman (the capital), Zarqa, and Irbid. Jordan is a small country with limited natural resources and a 13% unemployment rate in 2008. The bulk of Jordan’s labor force is engaged in providing services, 20% in industry and only 2.7% in agriculture. Jordan’s major exports include clothing, fertilizers, potash, phosphates, vegetables, and pharmaceuticals.
Adjunct Associate Professor of Pediatrics, University of Iowa
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References
Abdallah S, Ahmad AT, Batieha A, Ajlouni K (2007) Diabetes mellitus: the leading cause of haemodialysis in Jordan. East Mediterr Health J 13(4):803–9
Abdel-Aal NM, Ahmad AT, Froelicher ES, Batieha AM, Hamza MM, Ajlouni KM (2008) Prevalence of dyslipidemia in patients with type 2 diabetes in Jordan. Saudi Med J 29(10):1423–8
Abdel-Rahman F, Hussein A, Rihani R, Hlalah O, El Taani H, Sharma S, Nserat T, Sarhan M (2008) Bone marrow and stem cell transplantation at King Hussein cancer center. Bone Marrow Transplant 42(Suppl 1):S89–S91
Abu Alhaija ES, Hattab FN, al-Omari MA (2002) Cephalometric measurements and facial deformities in subjects with beta-thalassaemia major. Eur J Orthod 24(1):9–19
Abu Ali RM, Al Hajeri RM, Khader YS, Shegem NS, Ajlouni KM (2008) Sexual dysfunction in Jordanian diabetic women. Diabetes Care 31(8):1580–1
Abujbara MA, Hamamy HA, Jarrah NS, Shegem NS, Ajlouni KM (2004) Clinical and inheritance profiles of Kallmann syndrome in Jordan. Reprod Health 1(1):5
Adekile AD, Gu LH, Baysal E, Haider MZ, al-Fuzae L, Aboobacker KC, al-Rashied A, Huisman TH (1994) Molecular characterization of alpha-thalassemia determinants, beta-thalassemia alleles, and beta S haplotypes among Kuwaiti Arabs. Acta Haematol 92(4):176–81
Ahmad T, Zhang L, Gogus F, Verity D, Wallace G, Madanat W, Fayyad F, James T, Neville M, Kanawati C et al (2005) CARD15 polymorphisms in Behcet's disease. Scand J Rheumatol 34(3):233–7
Ahmad AT, Jbara MA, Hiyasat D, Bateiha A, Ajlouni KM (2007) The standard clinical smell testing protocol of the National Center for Diabetes, Endocrinology and Genetics in Amman, Jordan: JOR test. Am J Otolaryngol 28(6):388–91
Ahram D, Sato TS, Kohilan A, Tayeh M, Chen S, Leal S, Al-Salem M, El-Shanti H (2009) A homozygous mutation in ADAMTSL4 causes autosomal-recessive isolated ectopia lentis. Am J Hum Genet 84(2):274–8
Ajlouni KM, Arnaout MA, Qoussous Y (1996) Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities. J Endocrinol Invest 19(5):316–9
Ajlouni K, Jaddou H, Batieha A (1998a) Diabetes and impaired glucose tolerance in Jordan: prevalence and associated risk factors. J Intern Med 244(4):317–23
Ajlouni K, Jaddou H, Batieha A (1998b) Obesity in Jordan. Int J Obes Relat Metab Disord 22(7):624–8
Ajlouni K, Qusous Y, Khawaldeh AK, Jaddou H, Batiehah A, Ammari F, Zaheri M, Mashal A (1999) Incidence of insulin-dependent diabetes mellitus in Jordanian children aged 0-14 y during 1992–1996. Acta Paediatr Suppl 88(427):11–3
Ajlouni K, Jarrah N, El-Khateeb M, El-Zaheri M, El Shanti H, Lidral A (2002) Wolfram syndrome: identification of a phenotypic and genotypic variant from Jordan. Am J Med Genet 115(1):61–5
Ajlouni K, Khader YS, Batieha A, Ajlouni H, El-Khateeb M (2008) An increase in prevalence of diabetes mellitus in Jordan over 10 years. J Diabetes Complications 22(5):317–24
Al Qaddoumi AA (2006) Co-inheritance of alpha and beta-thalassemia in a Jordanian family. Clin Lab Sci 19(3):165–8
Al-Alami JR, Tayeh MK, Al-Sheyyab MY, El-Shanti HI (2002) Linkage analysis of a large inbred family with congenital megaloblastic anemia. Saudi Med J 23(10):1251–6
Al-Alami JR, Tayeh MK, Najib DA, Abu-Rubaiha ZA, Majeed HA, Al-Khateeb MS, El-Shanti HI (2003) Familial Mediterranean fever mutation frequencies and carrier rates among a mixed Arabic population. Saudi Med J 24(10):1055–9
Al-Alami JR, Tanner SM, Tayeh MK, de la Chapelle A, El-Shanti H (2005) Homozygous AMN mutation in hereditary selective intestinal malabsorption of vitamin B12 in Jordan. Saudi Med J 26(7):1061–4
Al-Aqtum MT, Al-Qawasmeh MH (2001) Prevalence of colour blindness in young Jordanians. Ophthalmologica 215(1):39–42
Al-Awadi SA, Farag TI, Teebi AS, Naguib K, el-Khalifa MY, Kelani Y, Al-Ansari A, Schimke RN (1985) Primary hypogonadism and partial alopecia in three sibs with mullerian hypoplasia in the affected females. Am J Med Genet 22(3):619–22
Al-Jaberi TM, El-Shanti H (2002) Diversity in polyp pathology and distribution of Familial Juvenile Polyposis Syndrome. Saudi Med J 23(3):328–31
Al-Maghribi H (2007) Congenital adrenal hyperplasia: problems with developmental anomalies of the external genitalia and sex assignment. Saudi J Kidney Dis Transpl 18(3):405–13
Almasri NM, Al Hamad M (2005) Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan. Breast Cancer Res 7(5):R598–604
Almasri NM, Al-Alami J, Faza M (2005) Bcl-2 gene rearrangement in Jordanian follicular and diffuse large B-cell lymphomas. Saudi Med J 26(2):251–5
Al-Mosawi ZS, Al-Saad KK, Ijadi-Maghsoodi R, El-Shanti HI, Ferguson PJ (2007) A splice site mutation confirms the role of LPIN2 in Majeed syndrome. Arthritis Rheum 56(3):960–4
Al-Qudah AA (1998) Clinical patterns of neuronal migrational disorders and parental consanguinity. J Trop Pediatr 44(6):351–4
Al-Qudah AA, Tarawneh M (1998) Congenital muscular dystrophy in Jordanian children. J Child Neurol 13(8):383–6
Al-Rimawi HS, Al-Sheyyab M, Batieha A, El-Shanti H, Abuekteish F (1999) Effect of desferrioxamine in acute haemolytic anaemia of glucose-6-phosphate dehydrogenase deficiency. Acta Haematol 101(3):145–8
Al-Rimawi HS, Jallad MF, Amarin ZO, Obeidat BR (2005) Hypothalamic-pituitary-gonadal function in adolescent females with beta-thalassemia major. Int J Gynaecol Obstet 90(1):44–7
Al-Rimawi HS, Abdul-Qader M, Jallad MF, Amarin ZO (2006) Acute splenic sequestration in female children with sickle cell disease in the North of Jordan. J Trop Pediatr 52(6):416–20
Al-Salem M (1990) Autosomal recessive ectopia lentis in two Arab family pedigrees. Ophthalmic Paediatr Genet 11(2):123–7
Al-Salem M (1991) Benign ocular manifestations of sickle cell anemia in Arabs. Indian J Ophthalmol 39(1):9–11
Al-Salem M (1997) Leber's congenital amaurosis in 22 affected members of one family. J Pediatr Ophthalmol Strabismus 34(4):254–7
Al-Salem M, Ismail L (1990) Ocular manifestations of sickle cell anaemia in Arab children. Ann Trop Paediatr 10(2):199–202
Al-Salem M, Rawashdeh N (1992) Pattern of childhood blindness and partial sight among Jordanians in two generations. J Pediatr Ophthalmol Strabismus 29(6):361–5
Al-Salem M, Rawashdeh N (1993) Consanguinity in north Jordan: prevalence and pattern. J Biosoc Sci 25(4):553–6
Al-Salem M, Arafat AF, Ismail L, Jaradat M (1996) Causes of blindness in Irbid, Jordan. Ann Saudi Med 16(4):420–3
Al-Sheyyab M, El Shanti H, Todd D, Shurman A (1996) Autosomal recessive lamellar ichthyosis and acute lymphoblastic leukemia. Eur J Hum Genet 4(2):105–7
Al-Sheyyab M, El-Shanti H, Ghariebeh N, Ektiesh F, Daoud AS (1998) Fanconi's anemia and primary hypothyroidism. Ann Saudi Med 18(1):58–9
Al-Sheyyab M, Daoud AS, El-Shanti H (2000) Chediak–Higashi syndrome: a report of eight cases from three families. Indian Pediatr 37(1):69–75
Al-Sheyyab M, Jarrah N, Younis E, Shennak MM, Hadidi A, Awidi A, El-Shanti H, Ajlouni K (2001) Bleeding tendency in Wolfram syndrome: a newly identified feature with phenotype genotype correlation. Eur J Pediatr 160(4):243–6
Al-Shroof M, Karnik AM, Karnik AA, Longshore J, Sliman NA, Khan FA (2001) Ciliary dyskinesia associated with hydrocephalus and mental retardation in a Jordanian family. Mayo Clin Proc 76(12):1219–24
Al-Till M, Jarrah NS, Ajlouni KM (2002) Ophthalmologic findings in fifteen patients with Wolfram syndrome. Eur J Ophthalmol 12(2):84–8
Al-Till MI, Al-Bdour MD, Ajlouni KM (2005) Prevalence of blindness and visual impairment among Jordanian diabetics. Eur J Ophthalmol 15(1):62–8
Al-Wahadneh AM, Dahabreh MM (2006) Familial Mediterranean fever in children: a single centre experience in Jordan. East Mediterr Health J 12(6):818–23
Amarin VN, Akasheh HF (2001) Advanced maternal age and pregnancy outcome. East Mediterr Health J 7(4–5):646–51
Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, Ajlouni K, Pandya A, Satin LS, El-Shanti H, Shiang R (2007) A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2. Am J Hum Genet 81(4):673–83
Aqrabawi HE (2008) Facial cleft and associated anomalies: incidence among infants at a Jordanian medical centre. East Mediterr Health J 14(2):356–9
Arnaout MA (1992) Late-onset congenital adrenal hyperplasia in women with hirsutism. Eur J Clin Invest 22(10):651–8
Atoum MF, Al-Hourani HM (2004a) Comparison of some risk factors between non-familial and familial breast cancer females in Jordan. Saudi Med J 25(2):168–71
Atoum MF, Al-Hourani HM (2004b) Lifestyle related risk factors for breast cancer in Jordanian females. Saudi Med J 25(9):1245–8
Atoum MF, Al-Kayed SA (2004) Mutation analysis of the breast cancer gene BRCA1 among breast cancer Jordanian females. Saudi Med J 25(1):60–3
Awadallah S, Hamad M (2000) The prevalence of type II diabetes mellitus is haptoglobin phenotype-independent. Cytobios 101(398):145–50
Awidi AS (1992) Rare inherited bleeding disorders secondary to coagulation factors in Jordan: a nine-year study. Acta Haematol 88(1):11–3
Awidi A, Shannak M, Bseiso A, Kailani MA, Kailani MA, Omar N, Anshasi B, Sakarneh N (1999) High prevalence of factor V Leiden in healthy Jordanian Arabs. Thromb Haemost 81(4):582–4
Badria LF, Amarin ZO (2003) Does consanguinity affect the severity of pre-eclampsia? Arch Gynecol Obstet 268(2):117–20
Badria LF, Abu-Heija A, Zayed F, Ziadeh SM, Alchalabi H (2001) Has consanguinity any impact on occurrence of pre-eclampsia and eclampsia? J Obstet Gynaecol 21(4):358–60
Baranathan V, Stanford MR, Vaughan RW, Kondeatis E, Graham E, Fortune F, Madanat W, Kanawati C, Ghabra M, Murray PI et al (2007) The association of the PTPN22 620W polymorphism with Behcet's disease. Ann Rheum Dis 66(11):1531–3
Barkawi M, Bashir N, Sharif L (1991) Sickle cell-thalassemia in a Jordanian family. Trop Geogr Med 43(1–2):94–9
Bashir N, Barkawi M, Sharif L (1992a) Sickle cell/beta-thalassemia in North Jordan. J Trop Pediatr 38(4):196–8
Bashir N, Barkawi M, Sharif L, Momani A, Gharaibeh N (1992b) Prevalence of hemoglobinopathies in north Jordan. Trop Geogr Med 44(1–2):122–5
Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL et al (2008) A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet 83(5):572–81
Berkovic SF, Mazarib A, Walid S, Neufeld MY, Manelis J, Nevo Y, Korczyn AD, Yin J, Xiong L, Pandolfo M et al (2005) A new clinical and molecular form of Unverricht-Lundborg disease localized by homozygosity mapping. Brain 128(Pt 3):652–8
Boehme DH, Shotar AO (1989) A complex deformity of appendicular skeleton and shoulder with congenital heart disease in three generations of a Jordanian family. Clin Genet 36(6):442–50
Brautbar C, Amar A, Cohen N, Oksenberg J, Cohen I, Kahana E, Bloch D, Alter M, Grosse-Wilde H (1982) HLA-D typing in multiple sclerosis: Israelis tested with European homozygous typing cells. Tissue Antigens 19(3):189–97
Buchanan DJ, Rapoport S (1952) Chemical comparison of normal meconium and meconium from a patient with meconium ileus. Pediatrics 9(3):304–10
Chan AO, Soliman AS, Zhang Q, Rashid A, Bedeir A, Houlihan PS, Mokhtar N, Al-Masri N, Ozbek U, Yaghan R et al (2005) Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries. Clin Cancer Res 11(23):8281–7
Christodoulou K, Zamba E, Tsingis M, Mubaidin A, Horani K, Abu-Sheik S, El-Khateeb M, Kyriacou K, Kyriakides T, Al-Qudah AK et al (2000) A novel form of distal hereditary motor neuronopathy maps to chromosome 9p21.1-p12. Ann Neurol 48(6):877–84
Cook R, Hanslip A (1966) Mortality among offspring of consanguineous marriage in a rural area of East Jordan. J Trop Pediatr Afr Child Health 11(4):95–9
Corut A, Senyigit A, Ugur SA, Altin S, Ozcelik U, Calisir H, Yildirim Z, Gocmen A, Tolun A (2006) Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. Am J Hum Genet 79(4):650–6
Dahabreh M, Najada A (2009) Pulmonary alveolar microlithiasis in an 8-month-old infant. Ann Trop Paediatr 29(1):55–9
Daoud AS, Batieha A, Bashtawi M, El-Shanti H (2003) Risk factors for childhood epilepsy: a case-control study from Irbid, Jordan. Seizure 12(3):171–4
Daoud AS, Ajloni S, El-Salem K, Horani K, Otoom S, Daradkeh T (2004) Risk of seizure recurrence after a first unprovoked seizure: a prospective study among Jordanian children. Seizure 13(2):99–103
Eid SS, Rihani G (2004) Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in 200 healthy Jordanians. Clin Lab Sci 17(4):200–2
Eid SS, Shubeilat T (2005) Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR G677A among 594 thrombotic Jordanian patients. Blood Coagul Fibrinolysis 16(6):417–21
el-Hazmi MA, Warsy AS, al-Swailem AR (1995) The frequency of 14 beta-thalassemia mutations in the Arab populations. Hemoglobin 19(6):353–60
El-Shanti HE (2001) Familial Mediterranean Fever. Saudi Med J 22(2):104–9
El-Shanti HI (2003) Familial mediterranean Fever and renal disease. Saudi J Kidney Dis Transpl 14(3):378–85
El-Shanti H (2004) Further delineation of El-Shanti syndrome. Eur J Pediatr 163(12):761–2
El-Shanti H, Al-Alami J (2002) The pattern of peripheral blood chromosomal abnormalities in Northern Jordan. Saudi Med J 23(12):1552–4
El-Shanti HI, Ferguson PJ (2007) Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res 462:11–9
El-Shanti HE, Omari HZ, Qubain HI (1997) Progressive pseudorheumatoid dysplasia: report of a family and review. J Med Genet 34(7):559–63
El-Shanti H, Murray JC, Semina EV, Beutow KH, Scherpbier T, Al-Alami J (1998) Assignment of gene responsible for progressive pseudorheumatoid dysplasia to chromosome 6 and examination of COL10A1 as candidate gene. Eur J Hum Genet 6(3):251–6
El-Shanti H, Al-Salem M, El-Najjar M, Ajlouni K, Beck J, Sheffiled VC, Stone EM (1999a) A nonsense mutation in the retinal specific guanylate cyclase gene is the cause of Leber congenital amaurosis in a large inbred kindred from Jordan. J Med Genet 36(11):862–5
El-Shanti HE, Daoud AS, Batieha A (1999b) A clinical study of a large inbred kindred with pure familial spastic paraplegia. Brain Dev 21(7):478–82
El-Shanti H, Lidral AC, Jarrah N, Druhan L, Ajlouni K (2000) Homozygosity mapping identifies an additional locus for Wolfram syndrome on chromosome 4q. Am J Hum Genet 66(4):1229–36
El-Shanti H, Ahmad M, Ajlouni K (2003) Alopecia universalis congenita, XY gonadal dysgenesis and laryngomalacia: a novel malformation syndrome. Eur J Pediatr 162(1):36–40
El-Shanti H, Daoud A, Sadoon AA, Leal SM, Chen S, Lee K, Spiegel R (2006a) A distinct autosomal recessive ataxia maps to chromosome 12 in an inbred family from Jordan. Brain Dev 28(6):353–7
El-Shanti H, Majeed HA, El-Khateeb M (2006b) Familial mediterranean fever in Arabs. Lancet 367(9515):1016–24
Enattah NS, Jensen TG, Nielsen M, Lewinski R, Kuokkanen M, Rasinpera H, El-Shanti H, Seo JK, Alifrangis M, Khalil IF et al (2008) Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. Am J Hum Genet 82(1):57–72
Ferguson PJ, El-Shanti HI (2007) Autoinflammatory bone disorders. Curr Opin Rheumatol 19(5):492–8
Ferguson PJ, Chen S, Tayeh MK, Ochoa L, Leal SM, Pelet A, Munnich A, Lyonnet S, Majeed HA, El-Shanti H (2005) Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome). J Med Genet 42(7):551–7
Gonzalez AM, Karadsheh N, Maca-Meyer N, Flores C, Cabrera VM, Larruga JM (2008) Mitochondrial DNA variation in Jordanians and their genetic relationship to other Middle East populations. Ann Hum Biol 35(2):212–31
Hadidi HF, Irshaid YM, Woosley RL, Idle JR, Flockhart DA (1995) S-mephenytoin hydroxylation phenotypes in a Jordanian population. Clin Pharmacol Ther 58(5):542–7
Hadidy AM, Jarrah NS, Al-Till MI, El-Shanti HE, Ajlouni KM (2004) Radiological findings in Wolfram syndrome. Saudi Med J 25(5):638–41
Hamamy H, Jamhawi L, Al-Darawsheh J, Ajlouni K (2005) Consanguineous marriages in Jordan: why is the rate changing with time? Clin Genet 67(6):511–6
Hamamy H, Al-Hait S, Alwan A, Ajlouni K (2007a) Jordan: communities and community genetics. Community Genet 10(1):52–60
Hamamy HA, Masri AT, Al-Hadidy AM, Ajlouni KM (2007b) Consanguinity and genetic disorders. Profile from Jordan. Saudi Med J 28(7):1015–7
Hamamy HA, Teebi AS, Oudjhane K, Shegem NN, Ajlouni KM (2007c) Severe hypertelorism, midface prominence, prominent/simple ears, severe myopia, borderline intelligence, and bone fragility in two brothers: new syndrome? Am J Med Genet A 143(3):229–34
Hamed RM (2002) The spectrum of chronic renal failure among Jordanian children. J Nephrol 15(2):130–5
Hamed RM (2003) Congenital nephrotic syndrome. Saudi J Kidney Dis Transpl 14(3):328–35
Hamed RM, Shomaf M (2001) Congenital nephrotic syndrome: a clinico-pathologic study of thirty children. J Nephrol 14(2):104–9
Hamed RM, Tamimi S, Al-Shamayleh A, Kamal MF, Tarawneh M, Toffaha A (1998) Renal cysts and associated malformations in pediatric autopsy material. Ann Saudi Med 18(5):451–3
Hampshire DJ, Roberts E, Crow Y, Bond J, Mubaidin A, Wriekat AL, Al-Din A, Woods CG (2001) Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36. J Med Genet 38(10):680–2
Handra-Luca A, Condroyer C, de Moncuit C, Tepper M, Flejou JF, Thomas G, Olschwang S (2005) Vessels' morphology in SMAD4 and BMPR1A-related juvenile polyposis. Am J Med Genet A 138A(2):113–7
Hart TC, Hart PS, Michalec MD, Zhang Y, Marazita ML, Cooper M, Yassin OM, Nusier M, Walker S (2000) Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation. J Med Genet 37(2):95–101
Hasan MA, Batieha A, Jadou H, Khawaldeh AK, Ajlouni K (2001) Growth status of Jordanian schoolchildren in military-funded schools. Eur J Clin Nutr 55(5):380–6
Hattab FN, Amin WM (2005) Papillon-Lefevre syndrome with albinism: a review of the literature and report of 2 brothers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100(6):709–16
Hattab FN, Rawashdeh MA, Yassin OM, al-Momani AS, al-Ubosi MM (1995) Papillon-Lefevre syndrome: a review of the literature and report of 4 cases. J Periodontol 66(5):413–20
Hattab FN, al-Khateeb T, Mansour M (1996) Oral manifestations of severe short-limb dwarfism resembling Grebe chondrodysplasia: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81(5):550–5
Hattab FN, Yassin OM, Sasa IS (1998) Oral manifestations of Ellis-van Creveld syndrome: report of two siblings with unusual dental anomalies. J Clin Pediatr Dent 22(2):159–65
Hattab FN, Hazza'a AM, Yassin OM, al-Rimawi HS (2001) Caries risk in patients with thalassaemia major. Int Dent J 51(1):35–8
Hewitt C, Wu CL, Hattab FN, Amin W, Ghaffar KA, Toomes C, Sloan P, Read AP, James JA, Thakker NS (2004) Coinheritance of two rare genodermatoses (Papillon-Lefevre syndrome and oculocutaneous albinism type 1) in two families: a genetic study. Br J Dermatol 151(6):1261–5
Hijazi SS, Abulaban A, Ammarin Z, Flatz G (1983) Distribution of adult lactase phenotypes in Bedouins and in urban and agricultural populations of Jordan. Trop Geogr Med 35(2):157–61
Hiyasat D, Dehyyat MA, Ajlouni S, Mubaidin AF, Till M, Hadidi A, El-Shanti H, Ajlouni KM (2002) Cerebellar hypoplasia, hypergonadotrophic hypogonadism, retinitis pigmentosa, alopecia, microcephaly, psychomotor retardation, and short stature: "D-CHRAMPS syndrome". Eur J Pediatr 161(3):170–2
Hosseini-Maaf B, Hellberg A, Rodrigues MJ, Chester MA, Olsson ML (2003) ABO exon and intron analysis in individuals with the AweakB phenotype reveals a novel O1v-A2 hybrid allele that causes four missense mutations in the A transferase. BMC Genet 4:17
Hosseini-Maaf B, Smart E, Chester MA, Olsson ML (2005) The Abantu phenotype in the ABO blood group system is due to a splice-site mutation in a hybrid between a new O1-like allelic lineage and the A2 allele. Vox Sang 88(4):256–64
Hurvitz JR, Suwairi WM, Van Hul W, El-Shanti H, Superti-Furga A, Roudier J, Holderbaum D, Pauli RM, Herd JK, Van Hul EV et al (1999) Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nat Genet 23(1):94–8
Irshaid YM, al-Hadidi HF, Rawashdeh NM (1993) Dextromethorphan O-demethylation polymorphism in Jordanians. Eur J Clin Pharmacol 45(3):271–3
Ismail SI, Sughayer MA, Al-Quadan TF, Qaqish BM, Tarawneh MS (2009) Frequency of t(14;18) in follicular lymphoma patients: geographical or technical variation. Int J Lab Hematol 31:535–545
Jaddou HY, Bateiha AM, Al-Khateeb MS, Ajlouni KM (2003) Epidemiology and management of hypertension among Bedouins in Northern Jordan. Saudi Med J 24(5):472–6
Janaydeh M, Hamad M, Awadallah S (2004) The relationship between haptoglobin polymorphism and serum ceruloplasmin ferroxidase activity. Clin Exp Med 3(4):219–23
Janson S, Dawani H (1994) Chronic illness in preschool Jordanian children. Ann Trop Paediatr 14(2):137–44
Janson S, Jayakoddy A, Abulaban A, Gustavson KH (1990) Severe mental retardation in Jordanian children. A retrospective study. Acta Paediatr Scand 79(11):1099–1104
Jarrah NS, El-Shanti H, Shennak MM, Ajlouni KM (1999) A case of Wolfram syndrome in triplets: some newly recognized features. Ann Saudi Med 19(2):132–4
Jarrah N, El-Shanti H, Khier A, Obeidat FN, Haddidi A, Ajlouni K (2000) Familial disorder of sex determination in seven individuals from three related sibships. Eur J Pediatr 159(12):912–8
Jbour AK, Mubaidin AF, Till M, El-Shanti H, Hadidi A, Ajlouni KM (2003a) Hypogonadotrophic hypogonadism, short stature, cerebellar ataxia, rod-cone retinal dystrophy, and hypersegmented neutrophils: a novel disorder or a new variant of Boucher–Neuhauser syndrome? J Med Genet 40(1):e2
Jbour AS, Jarrah NS, Radaideh AM, Shegem NS, Bader IM, Batieha AM, Ajlouni KM (2003b) Prevalence and predictors of diabetic foot syndrome in type 2 diabetes mellitus in Jordan. Saudi Med J 24(7):761–4
Kakish KS (2001) Cystic fibrosis in Jordan: clinical and genetic aspects. Bahrain Med Bull 23(4):157–159
Kakish KS (2002) Cystic fibrosis and infantile hypertrophic pyloric stenosis: is there an association? Pediatr Pulmonol 33(5):404–5
Karadsheh NS (1993) Pyruvate kinase (PK) deficiency in Jordan. Haematologica 78(2):80–3
Karadsheh NS, Gelbart T, Schulten HJ, Efferth T, Awidi A (2005a) Relationship between molecular variants and clinical manifestions in twelve glucose-6-phosphate dehydrogenase-deficient patients in Jordan. Acta Haematol 114(2):125–6
Karadsheh NS, Moses L, Ismail SI, Devaney JM, Hoffman E (2005b) Molecular heterogeneity of glucose-6-phosphate dehydrogenase deficiency in Jordan. Haematologica 90(12):1693–4
Khader Y, Bateiha A, El-Khateeb M, Al-Shaikh A, Ajlouni K (2007) High prevalence of the metabolic syndrome among Northern Jordanians. J Diabetes Complications 21(4):214–9
Khader Y, Batieha A, Ajlouni H, El-Khateeb M, Ajlouni K (2008) Obesity in Jordan: prevalence, associated factors, comorbidities, and change in prevalence over ten years. Metab Syndr Relat Disord 6(2):113–20
Khatib FA, Jarrah NS, Shegem NS, Bateiha AM, Abu-Ali RM, Ajlouni KM (2006) Sexual dysfunction among Jordanian men with diabetes. Saudi Med J 27(3):351–6
Khoury SA, Massad D (1992) Consanguineous marriage in Jordan. Am J Med Genet 43(5):769–75
Khoury SA, Massad DF (2000) Consanguinity, fertility, reproductive wastage, infant mortality and congenital malformations in Jordan. Saudi Med J 21(2):150–4
Kurdi-Haidar B, Mason PJ, Berrebi A, Ankra-Badu G, al-Ali A, Oppenheim A, Luzzatto L (1990) Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD-Mediterranean) in the Middle East. Am J Hum Genet 47(6):1013–9
Kury S, Dreno B, Bezieau S, Giraudet S, Kharfi M, Kamoun R, Moisan JP (2002) Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet 31(3):239–40
Lees AJ, Singleton AB (2007) Clinical heterogeneity of ATP13A2 linked disease (Kufor-Rakeb) justifies a PARK designation. Neurology 68(19):1553–4
Madanat WY, Madanat AY (2008) Worsening of osteomalacia in a patient successfully treated for neuro-Behcet's disease with infliximab. Clin Exp Rheumatol 26(4 Suppl 50):S128–9
Madanat WY, Prokaeva TB, Kotel'nikova GP, Alekberova ZS (1993) Endocarditis with left atrial thrombus formation in Behcet's disease mimicking myxoma. J Rheumatol 20(11):1982–4
Madanat W, Sharaiha Z, Khasawneh S, Zureikat H, Fayyad F (2003) Gastro-intestinal manifestations of Behcet's disease. Adv Exp Med Biol 528:455–7
Mahafza WS (2004) Multiple enchondromatosis Ollier's disease with two primary brain tumors. Saudi Med J 25(9):1261–3
Mahafza T, El-Shanti H, Omari H (2001) Raine syndrome: report of a case with hand and foot anomalies. Clin Dysmorphol 10(3):227–9
Mahasneh AA, Abdel-Hafiz SS (2004) Polymorphism of p53 gene in Jordanian population and possible associations with breast cancer and lung adenocarcinoma. Saudi Med J 25(11):1568–73
Mahdi AH, al-Mashhadani SA, al-Nasser M (1991) Wolman's disease in a Jordanian infant. Ann Trop Paediatr 11(3):305–8
Mahmoud IS, Sughayer MA, Mohammad HA, Awidi AS, EL-K MS, Ismail SI (2008) The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias. Br J Cancer 99(3):488–90
Majali H, Batieha AM, Jaddou HY, Khawaldeh A, Ajlouni KM (2003) Socio-economic discrepancies in growth status of Jordanian children in military-run schools at the turn of the twentieth century. Saudi Med J 24(5):548–9
Majeed HA, Kalaawi M, Mohanty D, Teebi AS, Tunjekar MF, al-Gharbawy F, Majeed SA, al-Gazzar AH (1989) Congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis in three related children and the association with Sweet syndrome in two siblings. J Pediatr 115(5 Pt 1):730–4
Majeed HA, Rawashdeh M, el-Shanti H, Qubain H, Khuri-Bulos N, Shahin HM (1999) Familial Mediterranean fever in children: the expanded clinical profile. QJM 92(6):309–18
Majeed HA, Al-Qudah AK, Qubain H, Shahin HM (2000a) The clinical patterns of myalgia in children with familial Mediterranean fever. Semin Arthritis Rheum 30(2):138–43
Majeed HA, El-Shanti H, Al-Rimawi H, Al-Masri N (2000b) On mice and men: an autosomal recessive syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anemia. J Pediatr 137(3):441–2
Majeed HA, Al-Tarawna M, El-Shanti H, Kamel B, Al-Khalaileh F (2001) The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review. Eur J Pediatr 160(12):705–10
Majeed HA, El-Shanti H, Al-Khateeb MS, Rabaiha ZA (2002) Genotype/phenotype correlations in Arab patients with familial Mediterranean fever. Semin Arthritis Rheum 31(6):371–6
Majeed HA, El-Khateeb M, El-Shanti H, Rabaiha ZA, Tayeh M, Najib D (2005) The spectrum of familial Mediterranean fever gene mutations in Arabs: report of a large series. Semin Arthritis Rheum 34(6):813–8
Masri A, Hamamy H (2006) Canavan disease: a first case from Jordan. J Pediatr Neurol 4:143–146
Masri AT, Hamamy HA (2007) Clinical and inheritance profiles of hyperekplexia in Jordan. J Child Neurol 22(7):895–900
Masri AT, Bakri FG, Al-Hadidy AM, Musharbash AF, Al-Hussaini M (2006) Ataxia-telangiectasia complicated by craniopharyngioma–a new observation. Pediatr Neurol 35(4):287–8
Masri A, Badran E, Hamamy H, Assaf A, Al-Qudah AA (2008a) Etiologies, outcomes, and risk factors for epilepsy in infants: a case-control study. Clin Neurol Neurosurg 110(4):352–6
Masri A, Bakri FG, Al-Hussaini M, Al-Hadidy A, Hirzallah R, de Saint BG, Hamamy H (2008b) Griscelli syndrome type 2: a rare and lethal disorder. J Child Neurol 23(8):964–7
Medlej-Hashim M, Rawashdeh M, Chouery E, Mansour I, Delague V, Lefranc G, Naman R, Loiselet J, Megarbane A (2000) Genetic screening of fourteen mutations in Jordanian familial Mediterranean fever patients. Hum Mutat 15(4):384
Medlej-Hashim M, Serre JL, Corbani S, Saab O, Jalkh N, Delague V, Chouery E, Salem N, Loiselet J, Lefranc G et al (2005) Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutations. Eur J Med Genet 48(4):412–20
Middleton LT, Christodoulou K, Mubaidin A, Zamba E, Tsingis M, Kyriacou K, Abu-Sheikh S, Kyriakides T, Neocleous V, Georgiou DM et al (1999) Distal hereditary motor neuronopathy of the Jerash type. Ann NY Acad Sci 883:439–42
Milhavet F, Cuisset L, Hoffman HM, Slim R, El-Shanti H, Aksentijevich I, Lesage S, Waterham H, Wise C, SarraustedeMenthiere C et al (2008) The infevers autoinflammatory mutation online registry: update with new genes and functions. Hum Mutat 29(6):803–8
Mitchell SC, Zhang AQ, Barrett T, Ayesh R, Smith RL (1997) Studies on the discontinuous N-oxidation of trimethylamine among Jordanian, Ecuadorian and New Guinean populations. Pharmacogenetics 7(1):45–50
Myhre R, Steinkjer S, Stormyr A, Nilsen GL, Abu Zayyad H, Horany K, Nusier MK, Klungland H (2008) Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile Parkinsonism. BMC Neurol 8:47
Nabulsi A (1995) Mating patterns of the Abbad tribe in Jordan. Soc Biol 42(3–4):162–74
Najim al-Din AS, al-Kurdi A, Dasouki M, Wriekat AL, al-Khateeb M, Mubaidin A, al-Hiari M (1994) Autosomal recessive ataxia, slow eye movements and psychomotor retardation. J Neurol Sci 124(1):61–6
Nazer HM (1992) Early diagnosis of cystic fibrosis in Jordanian children. J Trop Pediatr 38(3):113–5
Nusier M, Zhang Y, Yassin O, Hart TC, Hart PS (2002) Demonstration of altered splicing with the IVS3–1G –> a mutation of cathepsin C. Mol Genet Metab 75(3):280–3
Nusier M, Yassin O, Hart TC, Samimi A, Wright JT (2004) Phenotypic diversity and revision of the nomenclature for autosomal recessive amelogenesis imperfecta. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97(2):220–30
Nusier MK, Radaideh AM, Ababneh NA, Qaqish BM, Alzoubi R, Khader Y, Mersa JY, Irshaid NM, El-Khateeb M (2007) Prevalence of factor V G1691A (Leiden) and prothrombin G20210A polymorphisms among apparently healthy Jordanians. Neuro Endocrinol Lett 28(5):699–703
Obeidat BR, Khader YS, Amarin ZO, Kassawneh M, Al Omari M (2008) Consanguinity and Adverse Pregnancy Outcomes: The North of Jordan Experience. Matern Child Health J
Qublan HS, Eid SS, Ababneh HA, Amarin ZO, Smadi AZ, Al-Khafaji FF, Khader YS (2006) Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod 21(10):2694–8
Qublan H, Amarin Z, Dabbas M, Farraj AE, Beni-Merei Z, Al-Akash H, Bdoor AN, Nawasreh M, Malkawi S, Diab F et al (2008) Low-molecular-weight heparin in the treatment of recurrent IVF-ET failure and thrombophilia: a prospective randomized placebo-controlled trial. Hum Fertil (Camb) 11(4):246–53
Radaideh AR, Nusier MK, Amari FL, Bateiha AE, El-Khateeb MS, Naser AS, Ajlouni KM (2004) Thyroid dysfunction in patients with type 2 diabetes mellitus in Jordan. Saudi Med J 25(8):1046–50
Ramirez A, Heimbach A, Grundemann J, Stiller B, Hampshire D, Cid LP, Goebel I, Mubaidin AF, Wriekat AL, Roeper J et al (2006) Hereditary Parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet 38(10):1184–91
Rawashdeh MO, Majeed HA (1996) Familial Mediterranean fever in Arab children: the high prevalence and gene frequency. Eur J Pediatr 155(7):540–4
Rawashdeh M, Manal H (2000) Cystic fibrosis in Arabs: a prototype from Jordan. Ann Trop Paediatr 20(4):283–6
Rosenberg N, Hauschner H, Peretz H, Mor-Cohen R, Landau M, Shenkman B, Kenet G, Coller BS, Awidi AA, Seligsohn U (2005) A 13-bp deletion in alpha(IIb) gene is a founder mutation that predominates in Palestinian-Arab patients with Glanzmann thrombasthenia. J Thromb Haemost 3(12):2764–72
Roychoudhury AK, Nei M (1988) Human Polymorphic Genes: World Distribution. Oxford University Press, New York
Sadiq MF, Huisman TH (1994) Molecular characterization of beta-thalassemia in north Jordan. Hemoglobin 18(4–5):325–32
Sadiq MF, Eigel A, Horst J (2001) Spectrum of beta-thalassemia in Jordan: identification of two novel mutations. Am J Hematol 68(1):16–22
Saha N (1985) Distribution of transferrin C subtypes among the Bedouin and non-Bedouin populations of Jordan. Hum Hered 35(5):341–2
Saleh H, Davrinche C, Charlionet R, Rivat C (1986) Alpha-1-antitrypsin phenotypes in a population of Jordan. Hum Hered 36(3):192–4
Sanchez-Velasco P, Karadsheh NS, Garcia-Martin A, Ruiz de Alegria C, Leyva-Cobian F (2001) Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations. Hum Immunol 62(9):901–9
Shegem NS, Nasir AM, Jbour AK, Batieha AM, El-Khateeb MS, Ajlouni KM (2002) Effects of short term metformin administration on androgens in normal men. Saudi Med J 23(8):934–7
Shegem NS, Alsheek Nasir AM, Batieha AM, El-Shanti H, Ajlouni KM (2004) Effects of short term metformin administration on androgens in diabetic men. Saudi Med J 25(1):75–8
Srivastava T, Whiting JM, Garola RE, Dasouki MJ, Ruotsalainen V, Tryggvason K, Hamed R, Alon US (2001) Podocyte proteins in Galloway–Mowat syndrome. Pediatr Nephrol 16(12):1022–9
Sughayer MA, Al-Khawaja MM, Massarweh S, Al-Masri M (2006) Prevalence of hormone receptors and HER2/neu in breast cancer cases in Jordan. Pathol Oncol Res 12(2):83–6
Taher BM, Ajlouni HK, Hamamy HA, Shegem NS, Madanat AY, Ajlouni KM (2004) Precocious puberty at an endocrine centre in Jordan. Eur J Clin Invest 34(9):599–604
Takemoto Y, Naruse T, Namba K, Kitaichi N, Ota M, Shindo Y, Mizuki N, Gul A, Madanat W, Chams H et al (2008) Re-evaluation of heterogeneity in HLA-B*510101 associated with Behcet's disease. Tissue Antigens 72(4):347–53
Talafih K, Hunaiti AA, Gharaibeh N, Gharaibeh M, Jaradat S (1996) The prevalence of hemoglobin S and glucose-6-phosphate dehydrogenase deficiency in Jordanian newborn. J Obstet Gynaecol Res 22(5):417–20
Tamimi J, Madanat W (2003) Jordan friends of Behcet's disease patients society. A fruit of joint efforts between doctors and patients. Adv Exp Med Biol 528:609–11
Teebi AS, El-Shanti HI (2006) Consanguinity: implications for practice, research, and policy. Lancet 367(9515):970–1
Teebi AS, Dupuis L, Wherrett D, Khoury A, Zucker KJ (2004) Alopecia congenita universalis, microcephaly, cutis marmorata, short stature and XY gonadal dysgenesis: variable expression of El-Shanti syndrome. Eur J Pediatr 163(3):170–2
Touitou I, Sarkisian T, Medlej-Hashim M, Tunca M, Livneh A, Cattan D, Yalcinkaya F, Ozen S, Majeed H, Ozdogan H et al (2007) Country as the primary risk factor for renal amyloidosis in familial Mediterranean fever. Arthritis Rheum 56(5):1706–12
Usanga EA, Ameen R (2000) Glucose-6-phosphate dehydrogenase deficiency in Kuwait, Syria, Egypt, Iran, Jordan and Lebanon. Hum Hered 50(3):158–61
Verity DH, Vaughan RW, Madanat W, Kondeatis E, Zureikat H, Fayyad F, Kanawati CA, Ayesh I, Stanford MR, Wallace GR (1999a) Factor V Leiden mutation is associated with ocular involvement in Behcet disease. Am J Ophthalmol 128(3):352–6
Verity DH, Wallace GR, Vaughan RW, Kondeatis E, Madanat W, Zureikat H, Fayyad F, Marr JE, Kanawati CA, Stanford MR (1999b) HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behcet's disease. Tissue Antigens 54(3):264–72
Verity DH, Vaughan RW, Kondeatis E, Madanat W, Zureikat H, Fayyad F, Marr JE, Kanawati CA, Wallace GR, Stanford MR (2000) Intercellular adhesion molecule-1 gene polymorphisms in Behcet's disease. Eur J Immunogenet 27(2):73–6
Wahbeh AM, Ewais MH, Elsharif ME (2008) Spectrum of glomerulonephritis in adult Jordanians at Jordan university hospital. Saudi J Kidney Dis Transpl 19(6):997–1000
Wallace GR, Verity DH, Delamaine LJ, Ohno S, Inoko H, Ota M, Mizuki N, Yabuki K, Kondiatis E, Stephens HA et al (1999) MIC-A allele profiles and HLA class I associations in Behcet's disease. Immunogenetics 49(7–8):613–7
Wallace GR, Kondeatis E, Vaughan RW, Verity DH, Chen Y, Fortune F, Madanat W, Kanawati CA, Graham EM, Stanford MR (2007) IL-10 genotype analysis in patients with Behcet's disease. Hum Immunol 68(2):122–7
Wallerman O, Van Eeghen A, Ten Kate LP, Wadelius C (2003) Evidence for a second gene for primary microcephaly at MCPH5 on chromosome 1. Hereditas 139(1):64–7
Wang K, Pugh EW, Griffen S, Doheny KF, Mostafa WZ, al-Aboosi MM, el-Shanti H, Gitschier J (2001) Homozygosity mapping places the acrodermatitis enteropathica gene on chromosomal region 8q24.3. Am J Hum Genet 68(4):1055–60
Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J (2002) A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet 71(1):66–73
Williams DR, Hadeed A, al-Din AS, Wreikat AL, Lees AJ (2005) Kufor Rakeb disease: autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia. Mov Disord 20(10):1264–71
Yang X, Ahmad T, Gogus F, Verity D, Wallace GR, Madanat W, Kanawati CA, Stanford MR, Fortune F, Jewell DP et al (2004) Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behcet's disease. Eur J Immunogenet 31(1):11–4
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Dasouki, M., El-Shanti, H. (2010). Genetic Disorders in Jordan. In: Teebi, A. (eds) Genetic Disorders Among Arab Populations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05080-0_11
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