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Serotonergic Modulation of Sex and Aggression

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Hormones and Social Behaviour

Part of the book series: Research and Perspectives in Endocrine Interactions ((RPEI))

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Abstract

The serotonergic systemin the central nervous system (CNS) has complex interactions with many, if not all other neurotransmitter systems in the brain. Its localization, distribution and amazing receptor diversity makes it an appealing system formodulatory aspects in many basic behaviors, including sexual and aggressive behaviors. Notwithstanding decades of research into the putative role of the serotonin (5-HT) system in aggression and sex, no clear picture has emerged. In aggression, depending on state or trait, 5-HT is involved in either the performance or its termination. Application of drugs, and particular selective ligands for certain receptors, suggests a specific role for the (postsynaptic) 5-HT1B and to a lesser extent, the 5-HT1A receptor in themodulation of (offensive) aggression. In sexual behavior, the role of 5-HT is less well studied. Here, 5-HT1A receptor activation and blockade of 5-HT2C receptors are prosexual, whereas 5-HT1B receptor activation is inhibitory. Selective serotonergic uptake inhibitors have no acute effects on sexual behavior but are inhibitory after chronic administration. The role of serotonin in aggression and sexual behavior most likely involves different, partly overlapping, neurochemical systems, suggesting that independent networks in both behavioral systems are differentially influenced by serotonergic tone influencing various 5-HT receptors.

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Authors and Affiliations

  1. Department of Psychopharmacology,Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 36, 3584CA, Utrecht, Netherlands

    Berend Olivier, Johnny S.W. Chan & Marcel D. Waldinger

  2. Department of Psychiatry, Yale University School of Medicine, New Haven, USA

    Berend Olivier

  3. Haga-Hospital Leyenburg, Den Haag, Netherlands

    Marcel D. Waldinger

Authors
  1. Berend Olivier
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  2. Johnny S.W. Chan
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  3. Marcel D. Waldinger
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Editor information

Editors and Affiliations

  1. Lab. Neurobiology & Behavior, Rockefeller University, 1230 York Ave, 10021, New York, NY, USA

    Donald W. Pfaff

  2. Institut Necker, 156, rue de Vaugirard, 75015, Paris, France

    Claude Kordon

  3. Endocrinology and Reproductive Diseases, University Hospital Bicêtre, 78, rue du Général Leclerc, 94275, Le Kremlin-Bicêtre, France

    Philippe Chanson

  4. Pour la Recherche Thérapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris, France

    Yves Christen

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© 2008 Springer-Verlag Berlin Heidelberg

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Olivier, B., Chan, J., Waldinger, M. (2008). Serotonergic Modulation of Sex and Aggression. In: Pfaff, D., Kordon, C., Chanson, P., Christen, Y. (eds) Hormones and Social Behaviour. Research and Perspectives in Endocrine Interactions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79288-8_3

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  • DOI: https://doi.org/10.1007/978-3-540-79288-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-540-79288-8

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