Abstract
The 5-hydroxytryptamine (5-HT) reuptake inhibitors zimelidine (10 mg/kg IP 1.5 h pretest) or alaproclate (20 mg/kg IP 1.5 h pretest) produced a prolongation of the ejaculation latency and of the post-ejaculatory interval in male rats treated with a subthreshold dose of 5-hydroxytryptophan (5-HTP) (12.5 mg/kg IP 1 h pretest). The 5-HTP-induced (50 mg/kg IP 1 h pretest) prolongation of ejaculatory latency was effectively counteracted by administration of the 5-HT receptor blocking agent metergoline (1 mg/kg IP 1.5 h pretest). All animals were treated with an inhibitor of peripheral aromatic amino acid decarboxylase, indicating that the effects are of central origin. The results support the contention that central 5-HT plays an inhibitory role in male rat sexual behavior.
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Ahlenius, S., Eriksson, H., Larsson, K., Modigh, K., Södersten, P.: Mating behavior in the male rat treated with p-chlorophenylalanine methylester alone and in combination with pargyline. Psychopharmacologia 20, 383–388 (1971)
Ahlenius, S., Heimann, M., Larsson, K.: Prolongation of the ejaculation latency in the male rat by thioridazine and chlorimipramine. Psychopharmacology 65, 137–140 (1979)
Ahlenius, S., Larsson, K., Svensson, L.: Stimulating effects of lisuride on masculine sexual behavior of rats. Eur. J. Pharmacol., in press (1980)
Butcher, L., Butcher, S., Larsson, K.: Effects of apomorphine, (+)-amphetamine, and nialamide on tetrabenazine-induced suppression of sexual behavior in the male rat. Eur. J. Pharmacol. 7, 283–288 (1969)
Butcher, L., Engel, J., Fuxe, K.: l-dopa-induced changes in central monoamine neurons after peripheral decarboxylase inhibition. J. Pharm. Pharmacol. 22, 313–316 (1970)
Cocchi, D., Locatelli, V., Carminati, R., Müller, E. E.: Mechanisms underlying the prolactin-lowering effect of metergoline in the rat. Life Sci. 23, 927–936 (1978)
Eaton, H.: Chlorimipramine (Anafranil) in the treatment of premature ejaculation. J. Int. Med. Res. 1, 432–434 (1973)
Ferrini, R., Glässer, A. H.: Antagonism of central effects of tryptamine and 5-hydroxytryptophan by 1.6-dimethyl-8β-carbobenzyloxy-aminomethyl-10α-ergoline: Interference with amphetamine and dopa. Psychopharmacologia 8, 271–276 (1965)
Fuxe, K., Agnati, L., Everitt, B.: Effects of metergoline on central monoamine neurons. Evidence for a selective blockade of central 5-HT receptors. Neurosci. Letters 1, 283–290 (1975)
Gessa, G. L., Tagliamonte, A.: Role of brain serotonin and dopamine in male sexual behavior. In: Sexual behavior: Pharmacology and biochemistry, M. Sandler, G. L. Gessa, eds., pp. 117–128. New York: Raven 1975
Haigler, H. J., Aghajanian, G. K.: Peripheral serotonin antagonists: Failure to antagonize serotonin in brain areas receiving a prominent serotonergic input. J. Neural Transm. 35, 257–273 (1974)
Lindberg, M. H., Thorberg, S.-O., Bengtsson, S., Renyi, A. L., Ross, S. B., Ögren, S.-O.: Inhibitors of neuronal monoamine uptake. Selective inhibition of 5-hydroxytryptamine uptake by α-amino acid esters of phenethyl alcohols. J. Med. Chem. 21, 448–456 (1978)
Malmnäs, C. O.: Monoamine precursors and copulatory behavior in the male rat. Acta Physiol. Scand. (Suppl.) 395, 47–68 (1973a)
Malmnäs, C. O.: Effects of LSD-25, clonidine and apomorphine on copulatory behavior in the male rat. Acta Physiol. Scand. (Suppl.) 395, 96–116 (1973b)
Meyerson, B., Malmnäs, C. O.: Brain monoamines and sexual behavior. In: Biological determinants of sexual behavior, J. B. Hutchison, ed., pp. 521–554. Chichester: Wiley 1978
Paglietti, E., Pellegrini-Quarantotti, B., Mereu, G., Gessa, G. L.: Apomorphine and l-dopa lower ejaculation threshold in the male rat. Physiol. Behav. 20, 559–562 (1978)
Rogawski, M. A., Aghajanian, G. K.: Response of central monoaminergic neurons to lisuride: Comparison with LSD. Life Sci. 24, 1289–1298 (1979)
Ross, S. B., Ögren, S.-O., Renyi, A. L.: (Z)-Dimethylamino-1-(4-bromophenyl)-1-(3-pyridyl) propene (H102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake. Acta Pharmacol. Toxicol. (Kbh.) 39, 152–166 (1976)
Ross, S. B., Renyi, A. L.: Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues. Neuropharmacology 16, 57–64 (1977)
Salis, P. G., Dewsbury, D. A.: p-Chlorophenylalanine facilitates copulatory behavior in male rats. Nature 232, 400–401 (1971)
Sastry, B. S. R., Phillis, J. W.: Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex. Can. J. Physiol. Pharmacol. 55, 130–133 (1977)
Singh, H.: Therapeutic use of thioridazine in premature ejaculation. Am. J. Psychiatry 119, 891 (1963)
Södersten, P., Larsson, K., Ahlenius, S., Engel, J.: Sexual behavior in castrated male rats treated with monoamine synthesis inhibitors and testosterone. Pharmacol. Biochem. Behav. 5, 319–327 (1976a)
Södersten, P., Larsson, K., Ahlenius, S., Engel, J.: Stimulation of mounting behavior but not lordosis behavior in ovariectomized female rats by p-chlorophenylalanine. Pharmacol. Biochem. Behav. 5, 329–333 (1976b)
Tagliamonte, A., Fratta, W., DelFiacco, M., Gessa, G. L.: Possible stimulatory role of brain dopamine in the copulatory behavior of male rats. Pharmacol. Biochem. Behav. 2, 257–260 (1974)
Wang, R. Y., Aghajanian, G. K.: Collateral inhibition of serotonergic neurones in the rat dorsal raphe nucleus: Pharmacological evidence. Neuropharmacology 17, 819–825 (1978)
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Ahlenius, S., Larsson, K. & Svensson, L. Further evidence for an inhibitory role of central 5-HT in male rat sexual behavior. Psychopharmacology 68, 217–220 (1980). https://doi.org/10.1007/BF00428106
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DOI: https://doi.org/10.1007/BF00428106