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Biological Activity of Ginkgo

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Herbal Drugs: Ethnomedicine to Modern Medicine

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Abstract

The extract of Ginkgo biloba (Egb) contains more than 60 active substances with a high bioavailability. EGb has extensive protective effects on the central nervous system and cerebrovascular system. As neuroprotective agent it eliminates free radicals, acts as an antioxidant and a free-radical scavenger, reduces lipid peroxidation, and is a membrane stabilizer and an inhibitor of platelet-activating factor via the terpene ginkgolide. The anti-ischemic neuroprotective effects of Egb have been proved in cerebral and spinal cord ischemic models in animals, the action possibly being related to a functional state of mitochondria and apoptosis. However, high-quality and large-scale randomized controlled trials are needed to test its efficacy for the treatment of human stroke.

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Author information

Authors and Affiliations

  1. Jessenius Faculty of Medicine Department of Medical Biochemistry, Comenius University, Malá Hora 4 036 01 Martin, Slovak Republic

    Ján Lehotský

Authors
  1. Ján Lehotský
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  2. Peter Kaplan
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  3. Martina Pavlikova
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  4. Peter Urban
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  5. Beata Saniova
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Editors and Affiliations

  1. Botany Dept, M.L. Sukhadia University, Udaipur-313002, India

    K.G. Ramawat (Prof. Dr.) (Prof. Dr.)

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Lehotský, J., Kaplan, P., Pavlikova, M., Urban, P., Saniova, B. (2009). Biological Activity of Ginkgo. In: Ramawat, K. (eds) Herbal Drugs: Ethnomedicine to Modern Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79116-4_17

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