Autoinflammatory Disorders

  • Stefan Berg
  • Anders Fasth
  • Autoinflammatory disorders constitutes a new term that covers a group of diseases characterized by recurrent generalized inflammation in the absence of infectious or autoimmune causes.

  • Dysregulation of the innate immune system causes inflammation by affecting the pathways connected to the NOD-like receptors.

  • The patients are at risk of developing amyloidosis, the main long-term sequelae of many of these disorders.

  • The term was initially used only for the inherited periodic fever syndromes.

  • Over the past few years, the concept of autoinflammatory disorders has expanded to encompass an increasing number of polygenic/multifactorial diseases.


Familial Mediterranean Fever Periodic Fever Autoinflammatory Disease Chronic Recurrent Multifocal Osteomyelitis Systemic Onset Juvenile Idiopathic Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Stefan Berg
    • 1
  • Anders Fasth
    • 1
  1. 1.Department of PediatricsGöteborg University The Queen Silvia Children’s HospitalGöteborgSweden

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