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Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis

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Journal of Inherited Metabolic Disease

Summary

Hyper-IgD and periodic fever syndrome (HIDS) is a hereditary autoinflammatory syndrome, characterized by recurrent inflammatory attacks. Treatment of HIDS is difficult. Recently, the IL-1ra analogue anakinra was reported to be successful in aborting the IgD inflammatory attacks in a vaccination model. We report a clinical case of spectacular reduction of febrile attacks in a severe HIDS patient.

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Authors and Affiliations

  1. AP-HM Timone-Enfants, F-13385, Marseilles Cedex 05, France

    M. Cailliez, F. Garaix, C. Rousset-Rouvière, D. Bruno, J. Sarles, B. Chabrol & M. Tsimaratos

  2. Department of Pediatrics, Hôpital de Bicetre, Le Kremlin Bicetre, Paris, France

    I. Kone-Paut

Authors
  1. M. Cailliez
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  2. F. Garaix
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  3. C. Rousset-Rouvière
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  4. D. Bruno
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  5. I. Kone-Paut
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  6. J. Sarles
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  7. B. Chabrol
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  8. M. Tsimaratos
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Corresponding author

Correspondence to M. Tsimaratos.

Additional information

Communicating editor: Georg Hoffmann

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Cailliez, M., Garaix, F., Rousset-Rouvière, C. et al. Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis. J Inherit Metab Dis 29, 763 (2006). https://doi.org/10.1007/s10545-006-0408-7

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  • DOI: https://doi.org/10.1007/s10545-006-0408-7

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