Abstract
Analysis of DNA microarray images is a crucial step in gene expression analysis, as it influences the whole process for obtaining biological conclusions. When processing the underlying images, accurately separating the sub-grids is of supreme importance for subsequent steps. A method for separating the sub-grids is proposed, which aims to first, detect rotations in the images independently for the x and y axes, corrected by an affine transformation, and second, separate the corresponding sub-grids in the corrected image. Extensive experiments performed in various real-life microarray images from different sources show that the proposed method effectively detects and corrects the underlying rotations and accurately finds the sub-grid separations.
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Rueda, L. (2007). Sub-grid Detection in DNA Microarray Images. In: Mery, D., Rueda, L. (eds) Advances in Image and Video Technology. PSIVT 2007. Lecture Notes in Computer Science, vol 4872. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77129-6_24
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DOI: https://doi.org/10.1007/978-3-540-77129-6_24
Publisher Name: Springer, Berlin, Heidelberg
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