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The Relationship Between Tumors and the Lymphatics: Consequences for Metastasis

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Tumor Angiogenesis

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Abstract

Metastasis of tumor cells via the lymphatic vasculature is of major clinical relevance, and lymph node metastases are highly prognostically significant. Factors such as the structure of the lymphatic capillaries, tumor-induced lymphangiogenesis and the gene expression profiles expressed by the tumor cells all contribute to this process. Despite rapid progress in recent years, there is still much to be learned about the relationship between tumors and the lymphatics, particularly with regard to its significance in regulating metastatic spread to organs other than lymph nodes.

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Authors and Affiliations

  1. Institut für Genetik, Universität Karlsruhe, Karlsruhe

    PD Dr. Jonathan P. Sleeman

  2. Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, 76021, Karlsruhe, Germany

    PD Dr. Jonathan P. Sleeman

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  1. PD Dr. Jonathan P. Sleeman
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Editors and Affiliations

  1. Klinik für Tumorbiologie, Breisacher Str. 117, 79106, Freiburg i. Br., Germany

    Dieter Marmé PhD (Professor) (Professor)

  2. DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Norbert Fusenig MD (Professor, former Head of Division of Carcinogenesis and Differentiation) (Professor, former Head of Division of Carcinogenesis and Differentiation)

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© 2008 Springer-Verlag Berlin Heidelberg

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Sleeman, J.P. (2008). The Relationship Between Tumors and the Lymphatics: Consequences for Metastasis. In: Marmé, D., Fusenig, N. (eds) Tumor Angiogenesis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33177-3_19

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  • DOI: https://doi.org/10.1007/978-3-540-33177-3_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-33176-6

  • Online ISBN: 978-3-540-33177-3

  • eBook Packages: MedicineMedicine (R0)

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