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Evolving Genomics of Pulmonary Fibrosis

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Idiopathic Pulmonary Fibrosis

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Genome-scale transcript profiling approaches provide an unbiased view of the transcriptome of organs, tissues, and cells. In fibrotic lung diseases, such technologies have been applied to lungs and cells of patients and animal models of disease with the goal of identifying key molecules with a role in pathogenesis or to develop biomarkers of disease presence, progression, and outcome as well as to identify potential drug targets. Genomics profiling studies were also applied to classify and distinguish different interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and lung fibrosis associated with scleroderma and hypersensitivity pneumonitis (HP). In this chapter we describe the progress and insights derived from applying genome-scale transcript profiling approaches to fibrotic lung diseases as well as the potential impact of new technologies and National Institutes of Health (NIH)-funded projects on the field.

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Authors and Affiliations

  1. Section of Pulmonary Critical Care and Sleep Medicine, Internal Medicine Department, Yale School of Medicine, New Haven, CT, USA

    Gabriel Ibarra, Jose D. Herazo-Maya & Naftali Kaminski

  2. Pulmonary, Critical Care and Sleep Medicine Section, Internal Medicine Department, Yale University, New Haven, CT, USA

    Naftali Kaminski

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  1. Gabriel Ibarra
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    Keith C. Meyer

  2. Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, USA

    Steven D. Nathan

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Ibarra, G., Herazo-Maya, J.D., Kaminski, N. (2019). Evolving Genomics of Pulmonary Fibrosis. In: Meyer, K., Nathan, S. (eds) Idiopathic Pulmonary Fibrosis. Respiratory Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-99975-3_9

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