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Hematologic Impact of Fluid Replacement

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Hematologic Challenges in the Critically Ill

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Abstract

Intravenous fluids can be characterized as both fluids and as medications. They have a role in fluid and electrolyte homeostasis, as well as a local drug effect on the tissue bed. This chapter is focused on the composition of intravenous fluids, intravascular volume resuscitation, and the impact of fluids on electrolytes and acid-base balance – including the adverse effects of hyperchloremia on clinical outcomes, as well as the role of fluids in coagulation. Furthermore, this chapter discusses the endothelial glycocalyx, its role in fluid homeostasis, as well as the harmful effects of volume overload. Optimal volume management is briefly discussed within the context of goal-directed fluid management and large blood component replacement.

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Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA

    Christopher R. Barnes MD & Anthony M. Roche MBChB, FRCA, MMed

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  1. Christopher R. Barnes MD
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  2. Anthony M. Roche MBChB, FRCA, MMed
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Correspondence to Christopher R. Barnes MD .

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Editors and Affiliations

  1. Department of Anesthesiology, Critical Care and Hyperbaric Medicine, Team Health Research Institute, Englewood, NJ, USA

    Aryeh Shander

  2. Department of Critical Care Medicine, Geisinger Health System, Danville, PA, USA

    Howard L. Corwin

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Barnes, C.R., Roche, A.M. (2018). Hematologic Impact of Fluid Replacement. In: Shander, A., Corwin, H. (eds) Hematologic Challenges in the Critically Ill. Springer, Cham. https://doi.org/10.1007/978-3-319-93572-0_5

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  • DOI: https://doi.org/10.1007/978-3-319-93572-0_5

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