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Micellar-Based Nanoparticles for Cancer Therapy and Bioimaging

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Nanooncology

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

Abstract

Micelles are versatile nanosized systems composed by amphiphilic molecules. Their small size and capacity to encapsulate both hydrophilic and hydrophobic compounds, as well as their easier functionalization, are some of the characteristics responsible for their multifunctionality, and their potential use in different clinical settings. In fact, micelles have important applications in cancer therapy because of their capacity to deliver hydrophobic anticancer drugs to tumor sites. In recent years, applications beyond the delivery of hydrophobic drugs have been explored. In this chapter, we will discuss the main features of micelles that make them good candidates in the development of systems for cancer therapy and bioimaging. The state-of-the-art and recent advances in academic research and in clinical applications will be discussed

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Acknowledgements

This chapter is a result of the project NORTE-01-0145-FEDER-000012, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).

This work was partially funded by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). Andreia Almeida (grant SFRH/BD/118721/2016) and Fernanda Andrade (grant SFRH/BPD/120849/2016) would like to thank Fundação para a Ciência e a Tecnologia (FCT), Portugal for financial support.

This research was also partially supported by CESPU/IINFACTS under the project MicelCampt-CESPU-2017.

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Authors and Affiliations

  1. Drug Delivery and Targeting Group, CIBBIM-Nanomedicine, Vall D’Hebron Institut de Recerca (VHIR), Vall D’Hebron Barcelona Hospital Campus, 08035, Barcelona, Spain

    Fernanda Andrade, Diana Rafael & Simo Schwartz Jr

  2. i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-180, Porto, Portugal

    Fernanda Andrade, Andreia Almeida & Bruno Sarmento

  3. INEB—Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-180, Porto, Portugal

    Fernanda Andrade, Andreia Almeida & Bruno Sarmento

  4. ICBAS—Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, 4150-180, Porto, Portugal

    Andreia Almeida

  5. Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08035, Barcelona, Spain

    Simo Schwartz Jr

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  1. Fernanda Andrade
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  2. Andreia Almeida
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  3. Diana Rafael
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  4. Simo Schwartz Jr
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  5. Bruno Sarmento
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Correspondence to Fernanda Andrade or Bruno Sarmento .

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Editors and Affiliations

  1. Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Bellaterra, Spain

    Gil Gonçalves

  2. Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Bellaterra, Spain

    Gerard Tobias

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Andrade, F., Almeida, A., Rafael, D., Schwartz, S., Sarmento, B. (2018). Micellar-Based Nanoparticles for Cancer Therapy and Bioimaging. In: Gonçalves, G., Tobias, G. (eds) Nanooncology. Nanomedicine and Nanotoxicology. Springer, Cham. https://doi.org/10.1007/978-3-319-89878-0_6

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