Abstract
Heat shock proteins (HSP) belong to a family of stress-induced proteins essential to cell survival. HSP have multiple protective roles through assistance in protein folding, maintaining mitochondrial homeostasis, suppressing proinflammatory cytokines, resisting ischemic damage and protecting cells from apoptotic and necrotic death. This chapter discusses the important roles of HSP, particularly HSP70 in enhancing the survival of neurons in retinal disease through different pathways. Studies in various retinal cell lines, animal models and human tissue demonstrate altered HSP expression under different stresses and diseases. These findings implicate the critical role of. HSP in the diseased retina as well as providing support for translating the HSP’ cellular defense strategy into therapy to protect and rescue injured retina from different retinal pathology.
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Abbreviations
- AMD:
-
age-related macular degeneration
- DR:
-
diabetic retinopathy
- GGA:
-
geranylgeranylacetone
- HSP:
-
heat shock proteins
- LC-MS/MS:
-
liquid chromatography tandem-mass spectrometry
- NFκB:
-
nuclear factor-κB
- RGCs:
-
retinal ganglion cells
- RPE:
-
retinal pigment epithelium
- STZ:
-
streptozotocin
- TNF:
-
tumour necrosis factor
- VEGF:
-
vascular endothelial growth factor
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This work was supported in part by the University of Sydney Postgraduate Award (to B. B.) and Early Career Researcher Kick Start Grant from the Balnaves Foundation and Sydney Medical School (to L. Z.)
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Zhang, T., Bahrami, B., Zhu, L. (2018). Heat Shock Protein 70 and Other Heat Shock Proteins in Diseased Retina. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_14
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