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Mediators of Inflammation

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Immunopharmacology and Inflammation

Abstract

Inflammation is a physiologic response against noxious stimuli and microbial invaders. The basic elements of inflammation include host cells, blood vessels, proteins and lipid mediators, which work together to eliminate the inflammatory stimulus as well as initiate the resolution and repair. Mediators of inflammation are regulatory molecules that control the generation, maintenance and resolution of this response, which is triggered after recognition of infection or injure. The initial recognition of the inflammatory stimuli leads to the production of pro-inflammatory mediators. These mediators are derived from immune cells (e.g. vasoactive amines, lipid mediators, platelet-activating factor, reactive oxygen species, nitric oxide, cytokines and chemokines) or are acute phase proteins produced by the liver that circulate in the plasma (e.g. the complement, coagulation and kallikrein-kinin systems). Together, the mediators of inflammation orchestrate all the inflammatory events such as blood vessel dilatation, vascular permeability, leukocyte migration to the affected tissue and pain.

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Authors and Affiliations

  1. Laboratório de Sinalização da Inflamação, Departamento de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Izabela Galvão, Michelle A. Sugimoto & Lirlândia P. Sousa

  2. Laboratório de Sinalização da Inflamação, Departamento de Análises Clínicas e Toxicológicas da Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Juliana P. Vago & Marina G. Machado

  3. Laboratório de Sinalização da Inflamação, Departamento de Análises Clínicas e Toxicológicas da Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Lirlândia P. Sousa

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  1. Izabela Galvão
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  2. Michelle A. Sugimoto
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  3. Juliana P. Vago
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  1. Department of Medicine, Section of Pharmacology, University of Perugia, Perugia, Italy

    Carlo Riccardi

  2. Pharmacology and Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel

    Francesca Levi-Schaffer

  3. Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ekaterini Tiligada

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Galvão, I., Sugimoto, M.A., Vago, J.P., Machado, M.G., Sousa, L.P. (2018). Mediators of Inflammation. In: Riccardi, C., Levi-Schaffer, F., Tiligada, E. (eds) Immunopharmacology and Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-319-77658-3_1

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