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References
Thille AW, Cortés-Puch I, Esteban A (2013) Weaning from the ventilator and extubation in ICU. Curr Opin Crit Care 19:57–64
Béduneau G, Pham T, Schortgen F et al (2017) Epidemiology of weaning outcome according to a new definition. The WIND study. Am J Respir Crit Care Med 195:772–783
Epstein SK, Ciubotaru RL, Wong JB (1997) Effect of failed extubation on the outcome of mechanical ventilation. Chest 112:186–192
Thille AW, Harrois A, Schortgen F et al (2011) Outcomes of extubation failure in medical intensive care unit patients. Crit Care Med 39:2612–2618
Jung B, Moury PH, Mahul M et al (2016) Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failure. Intensive Care Med 42:853–861
Dres M, Dubé BP, Mayaux J et al (2017) Coexistence and impact of limb muscle and diaphragm weakness at time of liberation from mechanical ventilation in medical intensive care unit patients. Am J Respir Crit Care Med 195:57–66
Dubé BP, Dres M, Mayaux J, Demiri S, Similowski T, Demoule A (2017) Ultrasound evaluation of diaphragm function in mechanically ventilated patients: comparison to phrenic stimulation and prognostic implications. Thorax 72:811–818
Kim WY, Suh HJ, Hong SB et al (2011) Diaphragm dysfunction assessed by ultrasonography: influence on weaning from mechanical ventilation. Crit Care Med 39:2627–2630
Berger D, Bloechlinger S, von Haehling S et al (2016) Dysfunction of respiratory muscles in critically ill patients on the intensive care unit. J Cachexia Sarcopenia Muscle 7:403–412
Vassilakopoulos T, Petrof BJ (2004) Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 169:336–341
Levine S, Nguyen T, Taylor N et al (2008) Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 358:1327–1335
Welvaart WN, Paul MA, Stienen GJM et al (2011) Selective diaphragm muscle weakness after contractile inactivity during thoracic surgery. Ann Surg 254:1044–1049
American Thoracic Society, European Respiratory Society (2002) ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med 166:518–624
Moxham J, Goldstone J (1994) Assessment of respiratory muscle strength in the intensive care unit. Eur Respir J 7:2057–2061
Watson AC, Hughes PD, Harris LM et al (2001) Measurement of twitch transdiaphragmatic, esophageal, and endotracheal tube pressure with bilateral anterolateral magnetic phrenic nerve stimulation in patients in the intensive care unit. Crit Care Med 29:1325–1331
Vivier E, Mekontso Dessap A, Dimassi S et al (2012) Diaphragm ultrasonography to estimate the work of breathing during non-invasive ventilation. Intensive Care Med 38:796–803
Lerolle N, Guérot E, Dimassi S et al (2009) Ultrasonographic diagnostic criterion for severe diaphragmatic dysfunction after cardiac surgery. Chest 135:401–407
Dres M, Schmidt M, Ferre A et al (2012) Diaphragm electromyographic activity as a predictor of weaning failure. Intensive Care Med 38:2017–2025
Rozé H, Repusseau B, Perrier V et al (2013) Neuro-ventilatory efficiency during weaning from mechanical ventilation using neurally adjusted ventilatory assist. Br J Anaesth 111:955–960
Jung B, Nougaret S, Conseil M et al (2014) Sepsis is associated with a preferential diaphragmatic atrophy: a critically ill patient study using tridimensional computed tomography. Anesthesiology 120:1182–1191
Demoule A, Jung B, Prodanovic H et al (2013) Diaphragm dysfunction on admission to icu: prevalence, risk factors and prognostic impact – a prospective study. Am J Respir Crit Care Med 188:213–219
Aubier M, Trippenbach T, Roussos C (1981) Respiratory muscle fatigue during cardiogenic shock. J Appl Physiol 51:499–508
Jaber S, Petrof BJ, Jung B et al (2011) Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med 183:364–371
Hermans G, Agten A, Testelmans D et al (2010) Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study. Crit Care 14:R127
Grosu HB, Lee YI, Lee J et al (2012) Diaphragm muscle thinning in patients who are mechanically ventilated. Chest 142:1455–1460
Goligher EC, Fan E, Herridge MS et al (2015) Evolution of diaphragm thickness during mechanical ventilation: impact of inspiratory effort. Am J Respir Crit Care Med 192:1080–1088
Zambon M, Beccaria P, Matsuno J et al (2016) Mechanical ventilation and diaphragmatic atrophy in critically ill patients: an ultrasound study. Crit Care Med 44:1347–1352
Goligher EC, Dres M, Fan E et al (2017) Mechanical ventilation-induced diaphragm atrophy strongly impacts clinical outcomes. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.201703-0536OC (Sep 20 Epub ahead of print)
Garnacho-Montero J, Amaya-Villar R, García-Garmendía JL et al (2005) Effect of critical illness polyneuropathy on the withdrawal from mechanical ventilation and the length of stay in septic patients. Crit Care Med 33:349–354
De Jonghe B, Bastuji-Garin S, Durand MC et al (2007) Respiratory weakness is associated with limb weakness and delayed weaning in critical illness. Crit Care Med 35:2007–2015
Mrozek S, Jung B, Petrof BJ et al (2012) Rapid onset of specific diaphragm weakness in a healthy murine model of ventilator-induced diaphragmatic dysfunction. Anesthesiology 117:560–567
Blumhof S, Wheeler D, Thomas K et al (2016) Change in diaphragmatic thickness during the respiratory cycle predicts extubation success at various levels of pressure support ventilation. Lung 194:519–525
Ferrari G, De Filippi G, Elia F, Panero F, Volpicelli G, Aprà F (2014) Diaphragm ultrasound as a new index of discontinuation from mechanical ventilation. Crit Ultrasound J 6:8
DiNino E, Gartman EJ, Sethi JM, McCool FD (2014) Diaphragm ultrasound as a predictor of successful extubation from mechanical ventilation. Thorax 69:423–427
Farghaly S, Hasan AA (2017) Diaphragm ultrasound as a new method to predict extubation outcome in mechanically ventilated patients. Aust Crit Care 30:37–43
Sassoon CSH, Zhu E, Caiozzo VJ (2004) Assist-control mechanical ventilation attenuates ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 170:626–632
Gayan-Ramirez G, Testelmans D, Maes K et al (2005) Intermittent spontaneous breathing protects the rat diaphragm from mechanical ventilation effects. Crit Care Med 33:2804–2809
Reynolds SC, Meyyappan R, Thakkar V et al (2017) Mitigation of ventilator-induced diaphragm atrophy by transvenous phrenic nerve stimulation. Am J Respir Crit Care Med 195:339–348
Dres M, Teboul JL, Monnet X (2014) Weaning the cardiac patient from mechanical ventilation. Curr Opin Crit Care 20:493–498
Dres M, Teboul JL, Anguel N et al (2014) Extravascular lung water, B-type natriuretic peptide, and blood volume contraction enable diagnosis of weaning-induced pulmonary edema. Crit Care Med 42:1882–1889
Dres M, Roux D, Pham T et al (2017) Prevalence and impact on weaning of pleural effusion at the time of liberation from mechanical ventilation: a multicenter prospective observational study. Anesthesiology 126:1107–1115
Umbrello M, Mistraletti G, Galimberti A et al (2017) Drainage of pleural effusion improves diaphragmatic function in mechanically ventilated patients. Crit Care Resusc J 19:64–70
Martin AD, Smith BK, Davenport PD et al (2011) Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. Crit Care 15:R84
Bissett BM, Leditschke IA, Neeman T et al (2016) Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial. Thorax 71:812–819
Doorduin J, Sinderby CA, Beck J et al (2012) The calcium sensitizer levosimendan improves human diaphragm function. Am J Respir Crit Care Med 185:90–95
Gordon AC, Perkins GD, Singer M et al (2016) Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 375:1638–1648
Jiang JR, Tsai TH, Jerng JS et al (2004) Ultrasonographic evaluation of liver/spleen movements and extubation outcome. Chest 126:179–185
Lu Z, Xu Q, Yuan Y, Zhang G, Guo F, Ge H (2016) Diaphragmatic dysfunction is characterized by increased duration of mechanical ventilation in subjects with prolonged weaning. Respir Care 61:1316–1322
Supinski GS, Callahan LA (2013) Diaphragm weakness in mechanically ventilated critically ill patients. Crit Care 17:R120
Laghi F, Cattapan SE, Jubran A et al (2003) Is weaning failure caused by low-frequency fatigue of the diaphragm? Am J Respir Crit Care Med 167:120–127
Carrie C, Gisbert-Mora C, Bonnardel E et al (2017) Ultrasonographic diaphragmatic excursion is inaccurate and not better than the MRC score for predicting weaning-failure in mechanically ventilated patients. Anaesth Crit Care Pain Med 36:9–14
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Dres, M., Demoule, A. (2018). Diaphragm Dysfunction during Weaning from Mechanical Ventilation: An Underestimated Phenomenon with Clinical Implications. In: Vincent, JL. (eds) Annual Update in Intensive Care and Emergency Medicine 2018. Annual Update in Intensive Care and Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-73670-9_19
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