Diaphragm Dysfunction during Weaning from Mechanical Ventilation: An Underestimated Phenomenon with Clinical Implications

  • M. DresEmail author
  • A. Demoule
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


Weaning failure is defined as the inability to liberate a patient from the ventilator. Therefore, the term ‘weaning failure’ encompasses the failure of a spontaneous breathing trial (SBT) or the need to resume mechanical ventilation after extubation within 48 h to seven days [1]. The majority of patients are safely weaned from the ventilator after a first attempt, some are even extubated without any SBT [2]. Thereby, weaning failure occurs in a minority of patients but represents an important burden in term of days of mechanical ventilation, intensive care unit (ICU) lengths of stay and morbi‐mortality [2]. Investigating the causes of weaning failure is therefore crucial because the duration of mechanical ventilation for those who fail the SBT [2] and the reintubation for those in whom reintubation is needed [3, 4] have both been associated with poor outcomes. Ultimately, identifying the reason why a patient fails the weaning process might help to reduce the duration...


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.UPMC Univ Paris 06, INSERM, UMRS1158 Neurophysiologie respiratoire expérimentale et cliniqueSorbonne UniversitésParisFrance
  2. 2.Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale (Département ″R3S″)AP-HPParisFrance

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