Treatment of Myasthenia Gravis

  • Henry J. KaminskiEmail author
Part of the Current Clinical Neurology book series (CCNEU)


Effective therapy for the individual MG patient rests on balancing the risks and benefits of a wide range of therapeutic options. These risks not only include the dangers of severe weakness, limitations on employment, and complications of treatment but access to medications based on insurance company policies or government-set limitations. The typical patient who does not respond to cholinesterase inhibitor treatment will require prednisone and, if poorly responsive or with significant adverse effects, will need immunosuppressive therapy with azathioprine, tacrolimus, or mycophenolate. The treatment-resistant patient who fails corticosteroids and an immunosuppressive may benefit from a switch to another immunosuppressive or eculizumab. Despite the increasing number of excellently performed clinical trials, practice remains compromised by a limited evidence base, but the development of national guidelines for treatment has the promise of guiding clinicians not familiar with this rare disease to care for patients in a logical manner.


Acetylcholine receptor antibodies Azathioprine Eculizumab Methotrexate Myasthenia gravis Mycophenolate Prednisone Pyridostigmine Rituximab Tacrolimus Thymectomy Thymoma Thymus 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyThe George Washington UniversityWashington, DCUSA

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