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Coronary Heart Disease

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The Interventional Cardiology Training Manual

Abstract

Globally, cardiovascular disease (CVD) remains the leading cause of mortality and morbidity, accounting for some 18 million deaths worldwide in 2015, and this is expected to grow to >23.6 million by 2030. The biggest cause of cardiovascular death is ischemic heart disease (IHD), for both men and women. Global CVD rates rose by 12.5% between 2005 and 2015, with deaths attributable to IHD increasing by 16.6% to 8.9 million deaths, whilst age-standardised mortality rates fell by 12.8%, reflecting improved survival. IHD is largely attributable to atherosclerosis, a complex, chronic inflammatory process, determined by both genetic and environmental factors. Advances in the understanding of atherosclerotic plaque morphology, acute alterations in plaque morphology associated with acute coronary thrombotic events, and the complex interplay with a prothrombotic milieu and inflammation, have led to the concept of a “vulnerable patient”, rather than just a vulnerable plaque. There remains an important, ongoing need to further reduce mortality and morbidity from IHD, and an appreciation of the pathophysiology of IHD is essential to enable this.

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Authors and Affiliations

  1. National Heart and Lung Institute, Imperial College London, London, UK

    Diana Gorog

Authors
  1. Diana Gorog
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Correspondence to Diana Gorog .

Editor information

Editors and Affiliations

  1. Brighton and Sussex Medical School and the Sussex Cardiac Centre, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK

    Aung Myat

  2. Royal Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, UK

    Sarah Clarke

  3. Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK

    Nick Curzen

  4. Department of Cardiology, Bern University Hospital, Bern, Switzerland

    Stephan Windecker

  5. Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, VA, USA

    Paul A. Gurbel

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Gorog, D. (2018). Coronary Heart Disease. In: Myat, A., Clarke, S., Curzen, N., Windecker, S., Gurbel, P.A. (eds) The Interventional Cardiology Training Manual. Springer, Cham. https://doi.org/10.1007/978-3-319-71635-0_1

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  • DOI: https://doi.org/10.1007/978-3-319-71635-0_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-71633-6

  • Online ISBN: 978-3-319-71635-0

  • eBook Packages: MedicineMedicine (R0)

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