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Molecular Targeted Therapies of Prostate Cancer

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Precision Molecular Pathology of Prostate Cancer

Part of the book series: Molecular Pathology Library ((MPLB))

Abstract

Recent advances in androgen deprivation therapies for prostate cancer (PCa) have improved patient outcomes. In addition, metastatic biopsies enable a better molecular characterization of the evolving phenotype and underlying gene alterations. A novel landscape of druggable targets has been unraveled within several aberrant pathways, including androgen receptor (AR) signaling, proliferation, cell cycle progression, angiogenesis, immune evasion, epithelial-mesenchymal transition (EMT), stress response, DNA repair, and epigenetic regulation. The disease upon progression typically remains androgen-driven, but identification of true molecular drivers with direct or indirect association with AR signaling or totally androgen-independent as well as development and validation of surrogate markers of response are areas of active research. A plethora of established and promising new therapeutic strategies have emerged, and identifying the most effective combinations and sequencing is the key to further progress.

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Authors and Affiliations

  1. Division of Hematology and Medical Oncology, Department of Medicine, Meyer Cancer Center, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA

    Panagiotis J. Vlachostergios M.D., Ph.D., Marcia Paddock M.D., Ph.D. & Ana M. Molina M.D.

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  1. Panagiotis J. Vlachostergios M.D., Ph.D.
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  2. Marcia Paddock M.D., Ph.D.
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  3. Ana M. Molina M.D.
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Correspondence to Ana M. Molina M.D. .

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Editors and Affiliations

  1. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Brian D. Robinson

  2. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA

    Juan Miguel Mosquera

  3. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Jae Y. Ro

  4. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, Texas, USA

    Mukul Divatia

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Vlachostergios, P.J., Paddock, M., Molina, A.M. (2018). Molecular Targeted Therapies of Prostate Cancer. In: Robinson, B., Mosquera, J., Ro, J., Divatia, M. (eds) Precision Molecular Pathology of Prostate Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-64096-9_29

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