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Acridine on Dendrimeric Carriers

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Biomedical Applications of Acridines

Part of the book series: Progress in Drug Research ((PDR,volume 72))

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Abstract

Dendrimers are synthetic monodisperse polymers with a repeatedly branched, highly structured architecture adopting globular three-dimensional shape. Applications of dendrimers are very diverse. They can be used in physics, organic chemistry, biomedical applications, catalysis, and as solubilizing agents. Acridine-loaded dendrimers can serve as inhibitors of topoisomerase II and proteasome. Due to enhanced solubility and prolonged half-lives, they are superior than corresponding monomeric acridines in treatment of various cancers. Moreover, multiple presentation of acridines significantly increases biological activity of dendrimeric drugs much more than corresponds to the increase of acridine concentration. Brush-like dendrimers containing acridine units are suitable for delivery of gene across the blood–brain barrier.

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Authors and Affiliations

  1. Academy of Sciences, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

    Jan Ježek, Jan Hlaváček & Jaroslav Šebestík

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  1. Jan Ježek
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  2. Jan Hlaváček
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  3. Jaroslav Šebestík
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Correspondence to Jaroslav Šebestík .

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Ježek, J., Hlaváček, J., Šebestík, J. (2017). Acridine on Dendrimeric Carriers. In: Biomedical Applications of Acridines . Progress in Drug Research, vol 72. Springer, Cham. https://doi.org/10.1007/978-3-319-63953-6_9

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