Biomedical Applications of Acridines

Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases

  • Jan Ježek
  • Jan Hlaváček
  • Jaroslav Šebestík

Part of the Progress in Drug Research book series (PDR, volume 72)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 1-4
  3. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 5-8
  4. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 9-45
  5. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 47-71
  6. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 73-97
  7. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 99-134
  8. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 135-163
  9. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 165-186
  10. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 187-192
  11. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 193-206
  12. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 207-209
  13. Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
    Pages 211-211
  14. Back Matter
    Pages 213-237

About this book

Introduction

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can  be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

Keywords

Acridines acridine-protein interactions acridine-nucleic acid interactions neurodegenerative diseases labeling

Authors and affiliations

  • Jan Ježek
    • 1
  • Jan Hlaváček
    • 2
  • Jaroslav Šebestík
    • 3
  1. 1.Academy of SciencesInstitute of Organic Chemistry and BiochemistryPragueCzech Republic
  2. 2.Academy of SciencesInstitute of Organic Chemistry and BiochemistryPragueCzech Republic
  3. 3.Academy of SciencesInstitute of Organic Chemistry and BiochemistryPragueCzech Republic

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-63953-6
  • Copyright Information Springer International Publishing AG 2017
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-63952-9
  • Online ISBN 978-3-319-63953-6
  • Series Print ISSN 0071-786X
  • Series Online ISSN 2297-4555
  • About this book