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Familial Head and Neck Paraganglioma and Genetic Testing

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Contemporary Management of Jugular Paraganglioma

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Abstract

Paragangliomas are rare vascular tumors of neuroectodermal tissue arising from neural crest cells. They can be found at various locations of the paraganglion system throughout the body. Tumors originating from chromaffin cells of the adrenal medulla are referred to as pheochromocytomas. Most paragangliomas are benign, but morbidity can result from either growth and compression of nearby structures or physiologic derangements secondary to abnormal secretion of catecholamines. The vast majority of head and neck paragangliomas are nonsecretory [1, 2].

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Author information

Authors and Affiliations

  1. The Otology Group of Vanderbilt, Department of Otolaryngology, Vanderbilt University, Nashville, TN, 37232, USA

    Brendan P. O’Connell M.D.

  2. Department of Otolaryngology, Mount Sinai Health System, New York, NY, USA

    George B. Wanna M.D., F.A.C.S.

Authors
  1. Brendan P. O’Connell M.D.
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  2. George B. Wanna M.D., F.A.C.S.
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Correspondence to Brendan P. O’Connell M.D. .

Editor information

Editors and Affiliations

  1. Department of Otolaryngology, Mount Sinai Health System, New York, New York, USA

    George B. Wanna

  2. Department of Otolaryngology, Mayo Clinic School of Medicine, Rochester, New York, USA

    Matthew L. Carlson

  3. Center for Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    James L. Netterville

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O’Connell, B.P., Wanna, G.B. (2018). Familial Head and Neck Paraganglioma and Genetic Testing. In: Wanna, G., Carlson, M., Netterville, J. (eds) Contemporary Management of Jugular Paraganglioma. Springer, Cham. https://doi.org/10.1007/978-3-319-60955-3_15

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  • DOI: https://doi.org/10.1007/978-3-319-60955-3_15

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-60955-3

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