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Role of Non-coding RNAs in Vascular Complications of Diabetes Mellitus

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Mechanisms of Vascular Defects in Diabetes Mellitus

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 17))

Abstract

Non-coding RNAs (ncRNAs) have emerged as an important component of gene regulatory networks. These regulatory RNAs orchestrate different functions of the vascular system by regulating target gene expression. Significant dysregulation of ncRNAs is associated with hyperglycemia, angiogenesis and vascular repair and contribute to vascular disease in patients with diabetes. The functional roles of only a very few ncRNAs such as miRNAs are well studied in vascular biology; studies on other ncRNAs are limited. In this article, we outline the known roles of ncRNAs in diabetes associated vascular complications, as well as their potential use as biomarkers and therapeutic targets. We also discuss the strategies and challenges in the possible use of these microregulators for clinical application in patients with diabetes associated vascular diseases.

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Authors and Affiliations

  1. Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    Sumi Surendran Ph.D. & C. C. Kartha

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  1. Sumi Surendran Ph.D.
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  2. C. C. Kartha
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Correspondence to Sumi Surendran Ph.D. .

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Editors and Affiliations

  1. Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    C.C. Kartha

  2. Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    Surya Ramachandran

  3. Translational Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    Radhakrishna M. Pillai

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Surendran, S., Kartha, C.C. (2017). Role of Non-coding RNAs in Vascular Complications of Diabetes Mellitus. In: Kartha, C., Ramachandran, S., Pillai, R. (eds) Mechanisms of Vascular Defects in Diabetes Mellitus. Advances in Biochemistry in Health and Disease, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-60324-7_15

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