Abstract
Hypercalcemia is defined as serum [Ca2+] >11 mg/dL or 1 mg/dL above the normal range. It is a common electrolyte disorder that is frequently encountered by the primary care physicians. Hypercalcemia affects multiple organs in the body, including the kidney, heart, brain, peripheral nerves, and gut. Although causes of hypercalcemia are varied, they fall into four major categories (Table 19.1): (1) hypercalcemia secondary to increased Ca2+ mobilization from the bone, (2) hypercalcemia due to increased absorption of Ca2+ from the gastrointestinal tract (GI), (3) hypercalcemia due to decreased urinary excretion of Ca2+, and (4) hypercalcemia due to medications.
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Reference
Bilezikian JP, Khan AA, Potts JT Jr, on behalf of the Third International Workshop on the Management of Asymptomatic Primary Hyperthyroidism. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop. J Clin Endocrinol Metab. 2009;94:335–9.
Suggested Reading
Dumitru C, Wysolmerski J. Disorders of calcium metabolism. In: Alpern RJ, Moe OW, Caplan M, editors. Seldin and Giebisch’s the kidney. Physiology and pathophysiology. 5th ed. San Diego: Academic Press (Elsevier); 2013. p. 2273–309.
Hariri A, Mount DB, Rastegar A. Disorders of calcium, phosphorus, and magnesium metabolism. In: Mount DB, Sayegh MH, Singh AJ, editors. Core concepts in the disorders of fluid, electrolytes and acid-base balance. New York: Springer; 2013. p. 103–46.
Hoorn EJ, Zietse R. Disorders of calcium and magnesium balance: a physiology-based approach. Pediatr Nephrol. 2013;28:1195–206. doi:10.1007/s00467-012-2350-2.
Rosner MH, Dalkin AC. Onco-nephrology: the pathophysiology and treatment of malignancy-associated hypercalcemia. Clin J Am Soc Nephrol. 2012;7:1722–9.
Smogorzewski MJ, Stubbs JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Skorecki K, et al., editors. Brenner and Rector’s the kidney. 10th ed. Philadelphia: Elsevier; 2016. p. 601–35.
Stewart AF. Hypercalcemia associated with cancer. N Engl J Med. 2005;352:373–8.
Wysolmerski JJ. Parathyroid hormone-related protein: an update. J Clin Endocrinol Metab. 2012;97:2947–56.
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Reddi, A.S. (2018). Disorders of Calcium: Hypercalcemia. In: Fluid, Electrolyte and Acid-Base Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-60167-0_19
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DOI: https://doi.org/10.1007/978-3-319-60167-0_19
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