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The In Vivo Biology of the Mitochondrial Calcium Uniporter

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Mitochondrial Dynamics in Cardiovascular Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 982))

Abstract

The identification of the molecular composition of the mitochondrial calcium uniporter has allowed for the genetic manipulation of its components and the creation of various in vivo genetic models. Here, we review the initial attempts to modulate the expression of components of the calcium uniporter in a range of organisms from plants to mammals. This analysis has confirmed the strict requirement for the uniporter for in vivo mitochondrial calcium uptake and for maintaining mitochondrial calcium homeostasis. We further discuss the physiological effects following genetic manipulation of the uniporter on tissue bioenergetics and the threshold for cell death. Finally, we analyze the limited information regarding the role of various uniporter components in human disease.

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Authors and Affiliations

  1. Center for Molecular Medicine, National Heart Lung and Blood Institute, Bethesda, MD, 20892, USA

    Julia C. Liu, Jie Liu, Justin Stares, Ilsa I. Rovira & Toren Finkel MD, PhD

  2. Systems Biology Center, National Heart Lung and Blood Institute, Bethesda, MD, 20892, USA

    Randi J. Parks & Elizabeth Murphy

  3. NIH, Bldg 10/CRC 5-3330, Bethesda, MD, 20892, USA

    Toren Finkel MD, PhD

Authors
  1. Julia C. Liu
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  2. Randi J. Parks
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  3. Jie Liu
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  4. Justin Stares
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  5. Ilsa I. Rovira
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  6. Elizabeth Murphy
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  7. Toren Finkel MD, PhD
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Corresponding author

Correspondence to Toren Finkel MD, PhD .

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Editors and Affiliations

  1. Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy

    Gaetano Santulli

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Liu, J.C. et al. (2017). The In Vivo Biology of the Mitochondrial Calcium Uniporter. In: Santulli, G. (eds) Mitochondrial Dynamics in Cardiovascular Medicine. Advances in Experimental Medicine and Biology, vol 982. Springer, Cham. https://doi.org/10.1007/978-3-319-55330-6_3

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