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Simulating Stochastic Dynamic Interactions with Spatial Information and Flux

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Theory and Practice of Natural Computing (TPNC 2016)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 10071))

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Abstract

We present a conservative extension to rule based modeling languages with constructs for component attributes and functions that modify these attributes; the language has a stochastic semantics, and it is equipped with flux analysis. We show that the constructs of this language, called \(\mathsf {M}\), bring an ease especially in modeling biological systems, where spatial information is of essence. We discuss the language on models from molecular biology such as membrane diffusion systems, and actin polymerization networks, as well as models from ecology, where spatial behavior of animals as in bird flocks and fish schools are studied.

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Notes

  1. 1.

    Prototype modules that implement the language components are available for download at our website. http://sites.google.com/site/ozankahramanogullari/M.

  2. 2.

    https://www.youtube.com/watch?v=38KCf8nHQz0.

References

  1. Blinov, M.L., Faeder, J.R., Goldstein, B., Hlavacek, W.S.: BioNetGen: software for rule-based modeling of signal transduction based on the interactions of molecular domains. Bioinformatics 20, 3289–3292 (2004)

    Article  Google Scholar 

  2. Cardelli, L., Caron, E., Gardner, P., Kahramanoğulları, O., Phillips, A.: A process model of actin polymerisation. In: FBTC 2008, vol. 229. ENTCS, pp. 127–144. Elsevier (2008)

    Google Scholar 

  3. Cardelli, L., Zavattaro, G.: On the computational power of biochemistry. In: Horimoto, K., Regensburger, G., Rosenkranz, M., Yoshida, H. (eds.) AB 2008. LNCS, vol. 5147, pp. 65–80. Springer, Heidelberg (2008). doi:10.1007/978-3-540-85101-1_6

    Chapter  Google Scholar 

  4. DeAngelis, D.L., Gross, L.J.: Individual-based Models and Approaches in Ecology. Chapman and Hall, New York (1992)

    Book  Google Scholar 

  5. Feret, J., Danos, V., Krivine, J., Harmer, R., Fontana, W.: Internal coarse-graining of molecular systems. PNAS 106(16), 6453–6458 (2008)

    Article  Google Scholar 

  6. Gillespie, D.T.: Exact stochastic simulation of coupled chemical reactions. J. Phy. Chem. 81, 2340–2361 (1977)

    Article  Google Scholar 

  7. Gurry, T., Kahramanoğulları, O., Endres, R.: Biophysical mechanism for ras-nanocluster formation and signaling in plasma membrane. PLoS One. 4(7), e6148 (2009)

    Article  Google Scholar 

  8. Hemelrijk, C.K., Hildenbrandt, H.: Some causes of the variable shape of flocks of birds. PLoS One. 6(8), e22479 (2011)

    Article  Google Scholar 

  9. Hildenbrandt, H., Carere, C., Hemelrijk, C.K.: Self-organized aerial displays of thousands of starlings: a model. Behav. Ecol. 21(6), 1349–1359 (2010)

    Article  Google Scholar 

  10. Kahramanoğulları, O., Cardelli, L.: An intuitive modelling interface for systems biology. Int. J. Softw. Inf. 7(4), 655–674 (2013)

    Google Scholar 

  11. Kahramanoğulları, O., Cardelli, L.: Gener: a minimal programming module for chemical controllers based on DNA strand displacement. Bioinformatics (2015)

    Google Scholar 

  12. Kahramanoğulları, O., Morpurgo, D., Fantaccini, G., Lecca, P., Priami, C.: Algorithmic modeling quantifies the complementary contribution of metabolic inhibitions to gemcitabine efficacy. PLoS One. 7(12), e50176 (2012)

    Article  Google Scholar 

  13. Kahramanoğulları, O., Lynch, J.: Stochastic flux analysis of chemical reaction networks. BMC Systems Biol. 7(133) (2013)

    Google Scholar 

  14. Kahramanoğulları, O., Phillips, A., Vaggi, F., Process modeling, rendering of biochemical structures: actin. In: Lecca, P. (ed.) Biomechanics of Cells and Tissues: Experiments, Models and Simulations, vol. 9. LNCVB, pp. 45–63. Springer, Netherlands (2013)

    Google Scholar 

  15. Ollivier, J.F., Shahrezaei, V., Swain, P.S.: Scalable rule-based modelling of allosteric proteins and biochemical networks. PLoS Comput. Biol. 6(11), e1000975 (2010)

    Article  MathSciNet  Google Scholar 

  16. Phillips, A., Cardelli, L.: Efficient, Correct Simulation of Biological Processes in the Stochastic Pi-calculus. In: Calder, M., Gilmore, S. (eds.) CMSB 2007. LNCS, vol. 4695, pp. 184–199. Springer, Heidelberg (2007). doi:10.1007/978-3-540-75140-3_13

    Chapter  Google Scholar 

  17. Reynolds, C.W.: Flocks, herds and schools: a distributed behavioral model. ACM SIGGRAPH Comput. Graph., pp. 25–34 (1987)

    Google Scholar 

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Kahramanoğulları, O. (2016). Simulating Stochastic Dynamic Interactions with Spatial Information and Flux. In: Martín-Vide, C., Mizuki, T., Vega-Rodríguez, M. (eds) Theory and Practice of Natural Computing. TPNC 2016. Lecture Notes in Computer Science(), vol 10071. Springer, Cham. https://doi.org/10.1007/978-3-319-49001-4_12

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  • DOI: https://doi.org/10.1007/978-3-319-49001-4_12

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