Abstract
The absence of any effective drug therapy for underactive bladder makes the use of regenerative medicine approaches an attractive option. Tissue engineering of whole bladders has been investigated for over a decade and resulted in a small clinical study with some success, however such bladders can only fulfill a storage function due to the difficulty of recreating the complex neural innervation to enable volitional emptying. Stem cell injection therapy would be appear to be a more workable and practical approach in the patients with underactive bladder, however only pre-clinical studies are available. It is likely that any future stem cell injection approach should be tailored to the particular likely underlying pathophysiology, such as targeting the bladder wall in patients with myogenic failure.
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Aldamanhori, R., Osman, N.I., Chapple, C.R. (2017). Tissue Engineering and Cell Therapy for Underactive Bladder: Current and Future Approaches. In: Chapple, C., Wein, A., Osman, N. (eds) Underactive Bladder. Springer, Cham. https://doi.org/10.1007/978-3-319-43087-4_11
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