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Stem Cell Therapy in Neurological and Neurodegenerative Disease

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Neurological Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Neurological diseases affect the worldwide population. However, few effective therapies exist, in part due to the complexity of the central nervous system. Because neuronal loss is a hallmark of neurological and neurodegenerative disease, the compensatory therapeutic use of stem cells has important potential as a treatment option. Implanted stem cells can migrate into lesions of disease and generate new neurons as well as glial cells in vivo. Stem cell transplants can also produce neuroprotective molecules such as neurotrophic factors as a mechanism to improve disease outcome. Therefore, stem cell transplantation has potential as a powerful therapy for the regeneration of damaged central nervous system tissue. In this review, we discuss the therapeutic utility of different stem cell types and recent advancements in their use for the treatment of neurological and neurodegenerative disease.

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Acknowledgement

This research was supported by a grant from the Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program (KGM4611613).

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Authors and Affiliations

  1. Biomedical Research Institute, Chung-Ang University College of Medicine, Seoul, 06974, Republic of Korea

    Hong J. Lee PhD & Sung S. Choi

  2. National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, 363-883, Republic of Korea

    Sang-Rae Lee & Kyu-Tae Chang

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  1. Hong J. Lee PhD
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  2. Sung S. Choi
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  4. Kyu-Tae Chang
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Correspondence to Hong J. Lee PhD .

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  1. Laboratory of Stem Cell Research and Application, University of Science Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Lee, H.J., Choi, S.S., Lee, SR., Chang, KT. (2017). Stem Cell Therapy in Neurological and Neurodegenerative Disease. In: Pham, P. (eds) Neurological Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-33720-3_1

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