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Sensing and Remembering Cellular States Through Chromatin

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Manual of Cardiovascular Proteomics

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Abstract

Chromatin is the means by which the same genome encodes multiple cells: it enables orderly development, normal physiology and, when it goes haywire, malfunctioning chromatin is a hallmark of disease. In the cardiovascular system, the epigenomic features controlling gene expression have recently become the focus of intense research. This chapter examines the principles of chromatin structure, details their regulation and identifies areas of rapid development in our understanding of how the genome is packaged. Also explored are the recent observations indicating that deranged epigenomic features on a genome-wide scale may underpin various cardiovascular diseases.

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Acknowledgements

We thank Dr. Manuel Rosa Garrido for help with the figure and all members of the Vondriska laboratory for helpful discussions. Research in the Vondriska laboratory is supported by the National Heart, Lung and Blood Institute of the NIH, the American Heart Association, Thermo Fisher Scientific and the Department of Anesthesiology in the David Geffen School of Medicine at UCLA.

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  1. Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Shanxi Jiang BS & Thomas M. Vondriska PhD

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  1. Shanxi Jiang BS
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Correspondence to Thomas M. Vondriska PhD .

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  1. Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Giulio Agnetti

  2. Dept. of Physiology & Biophysics, University Mississippi Medical Center, Jackson, Mississippi, USA

    Merry L. Lindsey

  3. Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    D. Brian Foster

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Jiang, S., Vondriska, T.M. (2016). Sensing and Remembering Cellular States Through Chromatin. In: Agnetti, G., Lindsey, M., Foster, D. (eds) Manual of Cardiovascular Proteomics. Springer, Cham. https://doi.org/10.1007/978-3-319-31828-8_15

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